CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment☆
Section snippets
Evolution of the CTC
The evolution of various AE grading systems and the history of their modality origins have been reviewed elsewhere.3 Table 1 summarizes the most widely used systems over the last 20 years. In 1998, the NCI released a revised and markedly expanded version of the CTC (CTC v2.0) designed to update the original CTC. Among the changes was greater specificity in criteria language and the systematic inclusion of criteria for grading the acute effects of radiotherapy. This revision did not include
New principles of CTCAE v3.0
A number of new principles were established at the workshop regarding the need for fundamental changes in the methods of grading and reporting adverse effects.
Late effects and acute effects criteria will be merged into a single uniform system and applied without a predetermined time-based designation. In an era of complex multimodality integration, the designation of acute versus late effects (or subacute, consequential, and so on) will be a determination made by the investigator(s) upon
CTCAE v3.0
The third version of the CTC has been renamed as Common Terminology Criteria for Adverse Events v3.0 (CTCAE v3.0). The purpose of renaming is to move away from the term toxicity, which implies causation and does not fit the jargon commonly used across all modalities. It is scheduled for full distribution to NCI-sponsored organizations in the Spring of 2003 and will be available on the CTEP web site (http://ctep.info.nih.gov/CTC3/ctc/htm).10 It is anticipated that after October 2003 all
Summary
CTCAE v3.0 represents the first comprehensive, multimodality grading system to include both acute and late effects. We believe that it will greatly facilitate the standardized reporting of AEs, comparison of outcomes between trials and institutions, and promote a more complete recognition and reporting of adverse effects. This document has evolved over 20 years of use and has substantially matured in recent years to become a vital multimodality clinical trials tool. The development of CTCAE
References (11)
- et al.
Common toxicity criteriaVersion 2.0. An improved reference for grading the acute effects of cancer treatment: Impact on radiotherapy
Int J Radiat Oncol Biol Phys
(2000) The evolution and application of toxicity criteria
Semin Radiat Oncol
(2002)- et al.
Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)
Int J Radiat Oncol Biol Phys
(1995) - et al.
Overview of Late Effects of Normal Tissues (LENT) Scoring System
Int J Radiat Oncol Biol Phys
(1995) - et al.
Scoring of treatment-related late effects in prostate cancer
Radiat Oncol
(2002)
Cited by (2328)
Noninvasive Quantification of Radiation-Induced Lung Injury Using a Targeted Molecular Imaging Probe
2024, International Journal of Radiation Oncology Biology PhysicsClinical and Dosimetric Results of Proton or Photon Radiation Therapy for Large (>5 cm) Hepatocellular Carcinoma: A Retrospective Analysis
2024, International Journal of Radiation Oncology Biology PhysicsUpper-limb dysfunction in cancer survivors with chemotherapy-induced peripheral neurotoxicity
2024, Journal of the Neurological Sciences
- ☆
Supported by NCI R13 CA 93030-01.