The Role of Dna Methylation in Cancer
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2024, Computer Methods and Programs in BiomedicineComparative sequence analysis across Brassicaceae, regulatory diversity in KCS5 and KCS6 homologs from Arabidopsis thaliana and Brassica juncea, and intronic fragment as a negative transcriptional regulator
2020, Gene Expression PatternsCitation Excerpt :Seedlings grown in presence of 5-Aza showed an increase in reporter expression driven by AtKCS5 or AtKCS6 promoters as compared to that observed under control conditions. The increase in expression of reporter gene under demethylated conditions (in presence of 5-Aza) is in agreement with the general notion that methylation of cytosine present in the TFBS of promoter sequence of a gene leads to less sensitivity of TF towards its binding to TFBS, thereby downregulating transcription of a gene; lowering of C-methylation leads to opening of chromatin leading to increased access to TF ultimately causing increased gene expression (Jones and Buckley, 1990; Virmani et al., 2000; Zhou et al., 1996). The altered promoter activity when subjected to 5-Azacytidine suggests transcriptional regulation of AtKCS5 and AtKCS6 may be under control of cytosine methylation/demethylation.
Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/Ī-catenin and P53 signaling pathways
2019, Environmental PollutionCitation Excerpt :Epigenetic changes in tumor suppressor genes, including abnormalities of promoter methylation and changes in histone modification patterns, are essential for the development and progression of multiple cancers including liver cancer. The abnormal pattern of DNA methylation occurs in specific genes in almost all tumors, indicating that this change can be used as a molecular marker for cancer (Jones et al., 1990; Issa et al., 1999). For example, in HCC, abnormal methylation of several genes has been identified by the association between reduced mRNA levels and highly methylated promoters (Schagdarsurengin et al., 2003; Okochi et al., 2003; Miyoshi et al., 2004; Niwa et al., 2005).
Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease
2015, Experimental GerontologyImpact of zinc, selenium and lycopene on capsaicin induced mutagenicity and oxidative damage in mice
2013, Journal of Trace Elements in Medicine and BiologyEffect of CpG methylation on DNA binding protein: Molecular dynamics simulations of the homeodomain PITX2 bound to the methylated DNA
2011, Journal of Molecular Graphics and ModellingCitation Excerpt :Bird suggested that proper DNA methylation is a prerequisite for normal cell development and can be involved in a variety of processes, such as gene repression, imprinting, X-chromosome inactivation and suppression of repetitive genomic elements [2]. Many studies have demonstrated that aberrant CpG methylation is associated with a large number of human diseases including cancer [3ā8]. Furthermore, some recent studies show that DNA methylation is a potential biomarker for early detection and therapy monitoring of some cancers [9ā11].