Skip to main content

Advertisement

SpringerLink
Log in

Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

HOTAIR is a known long non-coding RNA which has recently been associated with the progression of some cancer types. It has been reported that HOTAIR expression is correlated with SUZ12 expression level and therefore may affect the epigenetic state of cancer tissues. Here, we found aberrant up-regulation of HOTAIR in gastric adenocarcinoma samples compared with normal adjacent gastric epithelium tissues. Besides, we found that the aberrant expression of HOTAIR was associated with TNM staging and lymph node metastasis of gastric tumors. Here, a potential cooperative expression between HOTAIR and SUZ12 genes in gastric adenocarcinoma tissues is deduced. This result suggests a role for HOTAIR long non-coding RNA in gastric cancer progression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Niland CN, Merry CR, Khalil AM. Emerging roles for long non-coding RNAs in cancer and neurological disorders. Front Genet. 2012;3:25.

    Article  PubMed  CAS  Google Scholar 

  2. Mitra SA, Mitra AP, Triche TJ. A central role for long non-coding RNA in cancer. Front Genet. 2012;3:17.

    Article  PubMed  CAS  Google Scholar 

  3. Bernstein E, Allis CD. RNA meets chromatin. Genes Dev. 2005;19:1635–55.

    Article  PubMed  CAS  Google Scholar 

  4. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464:1071–6.

    Article  PubMed  CAS  Google Scholar 

  5. Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, et al. Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 2011;71:6320–6.

    Article  PubMed  CAS  Google Scholar 

  6. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011;18:1243–50.

    Article  PubMed  Google Scholar 

  7. Yang F, Bi J, Xue X, Zheng L, Zhi K, Hua J, et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J. 2012;279:3159–65.

    Article  PubMed  CAS  Google Scholar 

  8. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods. 2001;25:402–8.

    Article  PubMed  CAS  Google Scholar 

  9. Spizzo R, Almeida MI, Colombatti A, Calin GA. Long non-coding RNAs and cancer: a new frontier of translational research? Oncogene. 2012;31:4577–87.

    Article  PubMed  CAS  Google Scholar 

  10. Hajjari M, Behmanesh M, Sadeghizadeh M, Zeinoddini M. Junctional adhesion molecules 2 and 3 may potentially be involved in progression of gastric adenocarcinoma tumors. Med Oncol. 2013;30:380.

    Article  PubMed  Google Scholar 

  11. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, et al. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2013;32:1616–25.

    Article  PubMed  CAS  Google Scholar 

  12. Nie Y, Liu X, Qu S, Song E, Zou H, Gong C. Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci. 2013;104:458–64.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors gratefully acknowledge the contribution of the patients and institutions in this study. The Iranian Council of Stem Cell Technology and the Department of Research Affairs of Tarbiat Modares University provided the funding for this work.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Genetics, School of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-154, Tehran, Iran

    Mohammadreza Hajjari, Mehrdad Behmanesh & Majid Sadeghizadeh

  2. Biotechnology Research Center, Mallek Ashtar University of Technology, Tehran, Iran

    Mehdi Zeinoddini

Authors
  1. Mohammadreza Hajjari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehrdad Behmanesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Majid Sadeghizadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mehdi Zeinoddini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mehrdad Behmanesh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hajjari, M., Behmanesh, M., Sadeghizadeh, M. et al. Up-regulation of HOTAIR long non-coding RNA in human gastric adenocarcinoma tissues. Med Oncol 30, 670 (2013). https://doi.org/10.1007/s12032-013-0670-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12032-013-0670-0

Keywords

Search

Navigation