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Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports

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Abstract

Primary breast lymphoma (PBL) is a rare form of extranodal non-Hodgkin’s lymphoma (NHL), whose own specific biological characteristics still need to be fully defined. No significant prognostic factor has been found and the optimal therapeutic strategy is uncertain. However, an intensified systemic therapy has been advocated to prevent relapse, even in patients who show a complete response to local treatment. We report two cases of primary diffuse large B-cell breast lymphoma, review the literature about this topic, and discuss treatment options. We conclude that differential therapeutic strategies based on the risk of relapse associated with the International Prognostic Index (IPI) are a reasonable way to approach PBL, and can avoid undue toxicity deriving from treatment.

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Abbreviations

PBL:

Primary breast lymphoma

NHL:

Non Hodgkin’s lymphoma

CNS:

Central nervous system

IPI:

International Prognostic Index

LDH:

Lactate dehydrogenase

ECOG:

Eastern Cooperative Oncology Group

CHOP:

Cyclophosphamide, doxorubicin, vincristine, and prednisolone

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Authors and Affiliations

  1. Department of Medical Sciences, Regina Apostolorum Hospital, Via S. Francesco, Albano Laziale, 5000041, Italy

    Roberto Stasi

  2. Division of Oncology and Hematology, Regina Apostolorum Hospital, Albano Laziale, Italy

    Roberto Stasi, Maria Laura Evangelista, Maurizio Brunetti, Stefano Bussa, Raffaele Maritati & Francesco Angelini

  3. Department of Pathology, Regina Apostolorum Hospital, Albano Laziale, Italy

    Luca Turrini, Silvia Taccogna & Anna Crescenzi

Authors
  1. Roberto Stasi
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  2. Maria Laura Evangelista
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  3. Maurizio Brunetti
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  4. Stefano Bussa
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  5. Raffaele Maritati
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  6. Luca Turrini
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  7. Silvia Taccogna
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  8. Anna Crescenzi
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  9. Francesco Angelini
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Correspondence to Roberto Stasi.

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Stasi, R., Evangelista, M.L., Brunetti, M. et al. Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports. Med Oncol 26, 22–26 (2009). https://doi.org/10.1007/s12032-008-9073-z

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  • DOI: https://doi.org/10.1007/s12032-008-9073-z

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