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Lung metastasectomy for postoperative colorectal cancer in patients with a history of hepatic metastasis

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Abstract

Objectives

Our objective was to evaluate the efficacy of pulmonary metastasectomy for postoperative colorectal cancer with hepatic metastasis, and to investigate the role of clinicopathological factors as predictors of outcome.

Methods

Consecutive patients undergoing pulmonary metastasectomy for colorectal cancer with (group PH, n = 27) or without (group P, n = 46) a history of hepatic metastasis were included in the study. Clinicopathological variables, including sex, age, site, carcinoembryonic antigen in the primary tumor, disease-free interval, prior hepatic resection, timing of pulmonary metastases, preoperative chemotherapy, type of pulmonary resection, and number, size, and location of pulmonary metastases were retrospectively collected and investigated for prognostic significance.

Results

Five-year survival rates were 59.5 and 70.0 % for patients with and without a history of hepatic metastasis, respectively; these values did not differ significantly. Among all investigated prognostic variables, sex and number of pulmonary metastases (1 vs. >1) were the most important factors affecting the outcome after colorectal and pulmonary resection. There was no significant difference in overall survival whether it was calculated from the time of resection of the primary colorectal cancer or of pulmonary metastases.

Conclusions

Pulmonary resection is not contraindicated in clinical practice. Significant factors indicating a good prognosis were female sex and the number of pulmonary metastases. Special attention should be paid to comparison of survival among studies.

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Acknowledgments

We thank Mie Makiguchi, nurse in the General Thoracic Surgery Outpatient Department; Misato Ichida, scientific secretary of General Thoracic Surgery; General Thoracic Surgery nursing staffs; and all staff members involved in this research protocol.

Conflict of interest

The authors declare that we have received no financial support and have no relationships that may pose a conflict of interest.

Author information

Authors and Affiliations

  1. Department of General Thoracic Surgery, Maebashi Red Cross Hospital, 3-21-36 Asahi-Cho, Maebashi, Gunma, 371-0014, Japan

    Mitsuhiro Kamiyoshihara, Hitoshi Igai, Natsuko Kawatani & Takashi Ibe

  2. Department of Gastroenterological Surgery, Maebashi Red Cross Hospital, Maebashi, Japan

    Naoki Tomizawa

  3. Division of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan

    Kai Obayashi, Kimihiro Shimizu & Izumi Takeyoshi

Authors
  1. Mitsuhiro Kamiyoshihara
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  2. Hitoshi Igai
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  3. Natsuko Kawatani
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  4. Takashi Ibe
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  5. Naoki Tomizawa
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  6. Kai Obayashi
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  7. Kimihiro Shimizu
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  8. Izumi Takeyoshi
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Corresponding author

Correspondence to Mitsuhiro Kamiyoshihara.

Additional information

This article is based on the Japanese paper: “Kamiyoshihara M, et al. Lung metastasectomy for postoperative colorectal cancer in patients with a history of hepatic metastasis. Kyobu Geka. 2013;66: 291–7. Japanese.”

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Kamiyoshihara, M., Igai, H., Kawatani, N. et al. Lung metastasectomy for postoperative colorectal cancer in patients with a history of hepatic metastasis. Gen Thorac Cardiovasc Surg 62, 314–320 (2014). https://doi.org/10.1007/s11748-014-0376-z

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  • DOI: https://doi.org/10.1007/s11748-014-0376-z

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