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A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres

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Abbreviations

IDH1:

Isocitrate dehydrogenase 1

α-KG:

α-Ketoglutarate

2-HG:

2-Hydroxyglutarate

GBM:

Glioblastoma

CIC:

Capicua transcriptional repressor

FUBP1:

Far-upstream binding protein 1

ATRX:

Alpha thalassemia/mental retardation syndrome X-linked

TP53:

Tumor protein p53

CDKN2A:

Cyclin-dependent kinase inhibitor 2A

ALT:

Alternative lengthening of telomeres

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Acknowledgments

We thank Meghan J. Seltzer, Vafi Salmasi, Gilson S. Baia, Zev A. Binder, Kelli M. Wilson and Andrew R. Larsen for technical assistance and constructive support.

Conflict of interest

GJR is co-inventor on intellectual property pertaining to the IDH1 mutation discover and receives royalties under licensing agreements managed by Johns Hopkins University in accordance with its conflict of interest policy.

Funding

This work was supported by the Conrad N. Hilton Foundation, the Virginia and D.K. Ludwig Fund for Cancer Research, and the Irving J. Sherman Professorship in Neurosurgery Research to GJR.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, School of Medicine, Johns Hopkins University, 1550 Orleans Street, Room 257 CRB2, Baltimore, MD, 21231, USA

    Alexandra Borodovsky, Qi Zhao, Gary L. Gallia & Gregory J. Riggins

  2. Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21231, USA

    Alan K. Meeker & Charles G. Eberhart

  3. J. Craig Venter Institute, Rockville, MD, 20850, USA

    Ewen F. Kirkness

Authors
  1. Alexandra Borodovsky
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  2. Alan K. Meeker
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  3. Ewen F. Kirkness
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  4. Qi Zhao
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  5. Charles G. Eberhart
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  6. Gary L. Gallia
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  7. Gregory J. Riggins
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Corresponding author

Correspondence to Gregory J. Riggins.

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Borodovsky, A., Meeker, A.K., Kirkness, E.F. et al. A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres. J Neurooncol 121, 479–487 (2015). https://doi.org/10.1007/s11060-014-1672-2

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  • DOI: https://doi.org/10.1007/s11060-014-1672-2

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