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B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case–control study in Greece

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Abstract

Aim

Leptin and adiponectin are two well-studied adipokines in relation to malignancies. In this study, we examined the association between leptin/adiponectin and risk of B-cell chronic lymphocytic leukemia (B-CLL), as well as the relationships between adipokines and several established prognostic factors of B-CLL.

Methods

Ninety-five patients with incident B-CLL and 95 hospital controls matched on age and gender were studied between 2001 and 2007, and blood samples were collected. Leptin, total and high molecular weight adiponectin, and prognostic markers of B-CLL were determined.

Results

Cases had a higher body mass index (BMI) than controls (p = 0.01) and lower levels of leptin (p < 0.01). Significantly more cases than controls presented a family history of lymphohematopoietic cancer (LHC) (p = 0.01). Higher serum leptin levels were associated with lower risk of B-CLL adjusting for age, gender, family history of LHC, BMI and serum adiponectin; the multivariate odds ratio comparing highest to lowest tertile was 0.05 (95% CI 0.01–0.29, p trend < 0.001); Adiponectin was not significantly different between cases and controls.

Conclusion

Leptin was found to be inversely associated with risk of CLL but in contrast to prior studies of CLL and hematologic malignancies, this study found no significant association between CLL and adiponectin.

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Acknowledgments

CM was supported by DK58785, DK79929 and DK81913 from the NIH, a discretionary grant from BIDMC, a grant-in-aid by Tanita Corporation and grant from the AICR. The authors would like to thank Dr. E. Kim for her contribution to statistical analysis of study variables considered in tertiles.

Conflict of interest statement

There is no conflict of interest related to this research.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Medical School, University of Athens, “Attikon” General University Hospital, 1 Rimini Street, Chaidari, 12462, Athens, Greece

    Maria Dalamaga & Amalia Dionyssiou-Asteriou

  2. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave., ST816, Boston, MA, 02215, USA

    Bradley H. Crotty, Jessica Fargnoli & Christos S. Mantzoros

  3. Division of Internal Medicine, Department of Dermatology, Medical School, University of Athens, “Attikon” General University Hospital, 1 Rimini Street, Chaidari, 12462, Athens, Greece

    Evangelia Papadavid

  4. Department of Laboratory Hematology, NIMTS General Hospital, 12 Monis Petraki and Vas.Sofias Avenue, 11521, Athens, Greece

    Antigoni Lekka & Maria Triantafilli

  5. Department of Internal Medicine, NIMTS General Hospital, 12 Monis Petraki and Vas.Sofias Avenue, 11521, Athens, Greece

    Konstantinos Karmaniolas & Ilias Migdalis

Authors
  1. Maria Dalamaga
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  2. Bradley H. Crotty
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  3. Jessica Fargnoli
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  9. Amalia Dionyssiou-Asteriou
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  10. Christos S. Mantzoros
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Correspondence to Christos S. Mantzoros.

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Dalamaga, M., Crotty, B.H., Fargnoli, J. et al. B-cell chronic lymphocytic leukemia risk in association with serum leptin and adiponectin: a case–control study in Greece. Cancer Causes Control 21, 1451–1459 (2010). https://doi.org/10.1007/s10552-010-9573-y

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  • DOI: https://doi.org/10.1007/s10552-010-9573-y

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