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Analysis of treatment that includes both hepatic and pulmonary resections for colorectal metastases

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Abstract

Purpose

Hepatic or pulmonary resections for colorectal metastases are regarded as standard treatment worldwide; however, the clinical significance of both hepatic and pulmonary resections for colorectal metastases remains undefined. We reviewed our clinical experience to evaluate the benefit of this treatment.

Methods

Between 1986 and 2010, 186 patients underwent potentially curative hepatic and/or pulmonary resections for colorectal metastases. Of these patients, 25 underwent both treatments (Group C), 100 underwent hepatic resections alone (Group H), and 61 underwent pulmonary resections alone (Group L). Univariate and multivariate analyses of the clinical and pathological variables in Group C and comparative survival analyses between Group C and Groups H–L were performed.

Results

In Group C, the median survival after primary tumor resection, initial metastasectomy, and last metastasectomy were 97, 60, and 35 months, respectively, and the 5-year overall survival rates were 63, 54, and 38 %, respectively. Multivariate analyses after initial metastasectomy revealed rectal tumors, multiple hepatic tumors, and simultaneous metastases as poor prognostic factors. Comparative survival analyses revealed no significant difference in overall survival between Group C and Groups H–L.

Conclusion

Hepatic and pulmonary resections for colorectal metastases improve survival and may even offer the potential for cure in selected patients.

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Conflict of interest

T. Matsui and his co-authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Departments of Colorectal Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, Tochigi, 320-0834, Japan

    Takashi Matsui, Tosuke Kitamura, Heita Ozawa & Kenjiro Kotake

  2. Thoracic Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, Tochigi, 320-0834, Japan

    Haruhisa Matsuguma

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  1. Takashi Matsui
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  2. Tosuke Kitamura
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Correspondence to Takashi Matsui.

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Matsui, T., Kitamura, T., Ozawa, H. et al. Analysis of treatment that includes both hepatic and pulmonary resections for colorectal metastases. Surg Today 44, 702–711 (2014). https://doi.org/10.1007/s00595-013-0769-0

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  • DOI: https://doi.org/10.1007/s00595-013-0769-0

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