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Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma

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Abstract

Purpose

Nutritional status has been associated with long-time outcomes in cancer patients. We investigated whether the prognostic nutritional index (PNI), an indicator of nutritional status, affects overall survival in patients with malignant pleural mesothelioma (MPM).

Methods

We enrolled 121 patients with histologically confirmed MPM, who had successfully undergone biopsy by medical thoracoscopy in this study. Demographic, clinical and laboratory data were collected retrospectively. The PNI was calculated as 10× serum albumin value (g/dl) + 0.005 × total lymphocyte count (per mm3) in peripheral blood. Univariate and multivariate analyses were used to identify prognostic factors.

Results

Mean pretreatment PNI was 44.6. PNI was significantly associated with age (P = 0.031), smoking habits (P = 0.039) and weight loss (P = 0.029). Survival analysis showed PNI to be an independent prognostic factor in MPM. Patients with lower PNIs (PNI < 44.6) had greater risk of death than those with higher PNIs (PNI ≥ 44.6; hazard ratio: 2.290; 95 % confidence interval: 1.415–3.706; P = 0.001). These analyses were adjusted for patient age, gender, smoking habits, dyspnea, chest pain, weight loss, primary site of tumor, histology, platinum-based systemic chemotherapy, hospital and stage.

Conclusions

Pretreatment PNI is a novel independent prognostic factor in MPM.

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Acknowledgments

We thank the staff at the Department of Respiratory Medicine of Shandong Provincial Hospital Affiliated to Shandong University and Qilu Hospital of Shandong University as well as the staff at the Department of Tuberculosis Medicine of Shandong Provincial Chest Hospital for their assistance in collecting the clinical data.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong Province, People’s Republic of China

    Zhou-Hong Yao, Yun-Yan Wan, Qing-Hua Liu & Dian-Jie Lin

  2. Department of Neurology, Jinan Children’s Hospital, Jinan, 250021, Shandong Province, People’s Republic of China

    Guang-Yan Tian

  3. Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Jinan, 250021, Shandong Province, People’s Republic of China

    Yan-Meng Kang

  4. Department of Respiratory Medicine, Dongying People’s Hospital, Dongying, 257000, Shandong Province, People’s Republic of China

    Hai-Sheng Guo

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  1. Zhou-Hong Yao
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Correspondence to Qing-Hua Liu or Dian-Jie Lin.

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Yao, ZH., Tian, GY., Wan, YY. et al. Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma. J Cancer Res Clin Oncol 139, 2117–2123 (2013). https://doi.org/10.1007/s00432-013-1523-0

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