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Radiotherapy-induced secondary cranial neoplasms in children

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Abstract

Background

Secondary malignant neoplasms (SMN) in CNS tumor survivors has become problem of increasing concern over the last 20 years. These tumors usually occur in a different site from the primary brain tumor several years after treatment.

Case report

We report secondary cranial malignant neoplasms in three patients who were treated with irradiation and chemotherapy for their primary brain tumors. The first case is a male survivor of an orbital rhabdomyosarcoma who developed a meningioma 8 years later. The other two cases are female survivors of ependymomas who were irradiated at the age of 3 and developed secondary gliomas 8 and 17 years after therapy respectively.

Conclusion

Patients carry a risk of developing SMNs many years later since irradiation is still an important part of the treatment. An SMN may have a benign course, as in meningioma, or be a dilemma for the patient, as in glioblastoma.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Oncology, Ege University School of Medicine, 35100, Izmir, Turkey

    Mehmet Kantar, Nazan Çetingül & Savaş Kansoy

  2. Department of Radiation Oncology, Ege University School of Medicine, 35100, Izmir, Turkey

    Yavuz Anacak

  3. Department of Pathology, Ege University School of Medicine, 35100, Izmir, Turkey

    Eren Demirtaş

  4. Department of Pediatric Neurosurgery, Ege University School of Medicine, 35100, Izmir, Turkey

    Yusuf Erşahin & Saffet Mutluer

Authors
  1. Mehmet Kantar
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  2. Nazan Çetingül
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  3. Savaş Kansoy
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  4. Yavuz Anacak
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  5. Eren Demirtaş
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  6. Yusuf Erşahin
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  7. Saffet Mutluer
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Correspondence to Mehmet Kantar.

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Kantar, M., Çetingül, N., Kansoy, S. et al. Radiotherapy-induced secondary cranial neoplasms in children. Childs Nerv Syst 20, 46–49 (2004). https://doi.org/10.1007/s00381-003-0798-x

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  • DOI: https://doi.org/10.1007/s00381-003-0798-x

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