Univariate and multivariate Cox regression analyses for OS in the entire cohort
| Clinicopathologic variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI for HR) | P | HR (95% CI for HR) | P | |
| Age | ||||
| > 63 years/≤ 63 years | 1.089 (0.953–1.270) | 0.128 | - | - |
| Gender | ||||
| Female/male | 0.942 (0.834–1.090) | 0.454 | - | - |
| Location | ||||
| Pancreatic head/pancreas other than the pancreatic head | 1.014 (0.902–1.186) | 0.605 | - | - |
| Chemotherapy first-line | ||||
| Gem-based/5-FU-based | 1.244 (1.090–1.419) | < 0.001 | 1.428 (1.261–1.621) | < 0.001 |
| Chemotherapy second-line | ||||
| Receiving chemotherapy/supportive care only | 0.766 (0.677–0.867) | < 0.001 | 0.232 (0.149–0.361) | < 0.001 |
| ECOG performance status | ||||
| ≥ 3/0–2 | 5.348 (4.566–6.289) | < 0.001 | 1.222 (0.780–1.912) | 0.381 |
| Distant metastasis | ||||
| Yes/no | 1.675 (1.357–2.068) | < 0.001 | 1.533 (1.240–1.895) | < 0.001 |
| Primary tumor size | ||||
| > 4 cm/≤ 4 cm | 0.930 (0.824–1.050) | 0.241 | - | - |
| Metastatic lesion size | ||||
| > 4 cm/≤ 4 cm | 0.926 (0.820–1.045) | 0.211 | - | - |
| Liver metastasis | ||||
| Yes/no | 1.358 (1.196–1.542) | < 0.001 | 1.235 (1.085–1.406) | 0.001 |
| Lung metastasis | ||||
| Yes/no | 1.032 (0.904–1.178) | 0.645 | - | - |
| Bone metastasis | ||||
| Yes/no | 1.170 (0.967–1.415) | 0.106 | - | - |
| Peritoneal metastasis | ||||
| Yes/no | 1.139 (0.988–1.314) | 0.072 | - | - |
| Lymph node metastasis | ||||
| Yes/no | 1.133 (1.001–1.283) | 0.048 | 1.107 (0.977–1.254) | 0.112 |
| CA19-9 | ||||
| > 200 U/mL/≤ 200 U/mL | 1.360 (1.205–1.565) | < 0.001 | 1.304 (1.151–1.477) | < 0.001 |