Table 2

Univariate and multivariate Cox models for PFS and OS in the secondary analysis

VariablesProgression-free survivalOverall survival
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
Age (> 54 vs. ≤ 54), years1.1 (0.4–3.2)0.8730.5 (0.1–3.9)0.5461.6 (0.5–5.2)0.3990.3 (0.0–3.6)0.365
Gender (female vs. male)0.8 (0.3–2.3)0.6351.7 (0.5–5.8)0.4281.1 (0.4–3.5)0.8272.6 (0.6–10.1)0.184
KPS (≥ 90 vs. 60–80)1.2 (0.4–3.7)0.8100.8 (0.2–4.7)0.8491.6 (0.5–5.3)0.4581.4 (0.1–12.5)0.792
Resection0.7870.5000.4140.140
 NTR vs. GTR1.2 (0.3–5.4)0.7962.1 (0.4–10.8)0.3962.2 (0.4–10.9)0.3575.1 (0.7–34.9)0.330
 STR vs. GTR1.6 (0.4–5.5)0.4952.6 (0.5–13.9)0.2502.4 (0.6–9.7)0.2185.9 (0.9–38.5)0.681
HEG1 (mutant vs. wild-type)5.6 (1.3–23.7)0.0216.0 (1.2–28.8)0.0262.8 (0.7–10.3)0.1322.5 (0.6–10.1)0.210
RP1L1 (mutant vs. wild-type)11.1 (2.2–57.2)0.00412.5 (2.1–74.3)0.00533.8 (3.4–334.5)0.00333.4 (3.2–351.4)0.003

GTR, gross total resection; KPS, Karnofsky performance status; NTR, near-total resection; OS, overall survival; PFS, progression-free survival. One hypermutator case with tumor mutational burden (TMB) = 327.7 was excluded from analysis.