Summary of any-grade TRAEs occurring in ≥ 5% of patients and all TRAEs of grade 3 or 4
| Adverse event | Any grade n (%) | Grade 1 or 2 n (%) | Grade 3 or 4 n (%) |
|---|---|---|---|
| All | 21 (100.0) | 21 (100.0) | 11 (52.4) |
| Hypomagnesemia | 16 (76.2) | 11 (52.4) | 7 (33.3) |
| Rash | 10 (47.6) | 8 (38.1) | 2 (9.5) |
| Acneiform dermatitis | 9 (42.9) | 8 (38.1) | 2 (9.5) |
| Proteinuria | 8 (38.1) | 8 (38.1) | 0 |
| Increased blood alkaline phosphatase | 4 (19.0) | 4 (19.0) | 0 |
| Hyperthyroidism | 4 (19.0) | 4 (19.0) | 0 |
| Paronychia | 3 (14.3) | 3 (14.3) | 0 |
| Increased aspartate transferase | 2 (9.5) | 2 (9.5) | 0 |
| Increased alanine transferase | 2 (9.5) | 2 (9.5) | 0 |
| Hyperthyroidism | 2 (9.5) | 2 (9.5) | 0 |
| Hypothyroidism | 2 (9.5) | 2 (9.5) | 0 |
| Cough | 2 (9.5) | 2 (9.5) | 0 |
| Immune-mediated dermatitis | 1 (4.8) | 0 | 1 (4.8) |
| Atopic dermatitis | 1 (4.8) | 0 | 1 (4.8) |
| Hypokalemia | 1 (4.8) | 0 | 1 (4.8) |
| Increased creatine phosphokinase | 1 (4.8) | 0 | 1 (4.8) |
| Increased myoglobin levels | 1 (4.8) | 0 | 1 (4.8) |
| Skin infection | 1 (4.8) | 0 | 1 (4.8) |
n, number.