Table 6

Grade 3 or 4 AEs (n = 245)

First-line chemotherapy regimenP value
GS (n = 67)GnP (n = 178)
Overall0.329
 No25 (37.3%)53 (29.8%)
 Yes42 (62.7%)125 (70.2%)
Hematologic
Leukopenia0.049
 No57 (85.1%)128 (71.9%)
 Yes10 (14.9%)50 (28.1%)
Neutropenia0.988
 No35 (52.2%)95 (53.4%)
 Yes32 (47.8%)83 (46.6%)
Thrombocytopenia0.386
 No60 (89.6%)167 (93.8%)
 Yes7 (10.4%)11 (6.2%)
Anemia0.839
 No64 (95.5%)167 (93.8%)
 Yes3 (4.5%)11 (6.2%)
Nonhematologic
Fatigue0.839
 No64 (95.5%)167 (93.8%)
 Yes3 (4.5%)11 (6.2%)
Nausea0.614
 No64 (95.5%)174 (97.8%)
 Yes3 (4.5%)4 (2.2%)
Vomiting0.896
 No66 (98.5%)173 (97.2%)
 Yes1 (1.5%)5 (2.8%)
Rash1.000
 No64 (95.5%)170 (95.5%)
 Yes3 (4.5%)8 (4.5%)
Diarrhea0.893
 No65 (97.0%)175 (98.3%)
 Yes2 (3.0%)3 (1.7%)
Anorexia1.000
 No64 (95.5%)170 (95.5%)
 Yes3 (4.5%)8 (4.5%)
Bilirubin0.085
 No63 (94.0%)176 (98.9%)
 Yes4 (6.0%)2 (1.1%)
ALT/AST1.000
 No66 (98.5%)175 (98.3%)
 Yes1 (1.5%)3 (1.7%)
Hand-foot syndrome0.611
 No66 (98.5%)178 (100.0%)
 Yes1 (1.5%)0 (0.0%)
Oral mucositis0.085
 No63 (94.0%)176 (98.9%)
 Yes4 (6.0%)2 (1.1%)
Peripheral neuropathy0.135
 No67 (100.0%)169 (94.9%)
 Yes0 (0.0%)9 (5.1%)