Grade 3 or 4 AEs (n = 245)
| First-line chemotherapy regimen | P value | ||
|---|---|---|---|
| GS (n = 67) | GnP (n = 178) | ||
| Overall | 0.329 | ||
| No | 25 (37.3%) | 53 (29.8%) | |
| Yes | 42 (62.7%) | 125 (70.2%) | |
| Hematologic | |||
| Leukopenia | 0.049 | ||
| No | 57 (85.1%) | 128 (71.9%) | |
| Yes | 10 (14.9%) | 50 (28.1%) | |
| Neutropenia | 0.988 | ||
| No | 35 (52.2%) | 95 (53.4%) | |
| Yes | 32 (47.8%) | 83 (46.6%) | |
| Thrombocytopenia | 0.386 | ||
| No | 60 (89.6%) | 167 (93.8%) | |
| Yes | 7 (10.4%) | 11 (6.2%) | |
| Anemia | 0.839 | ||
| No | 64 (95.5%) | 167 (93.8%) | |
| Yes | 3 (4.5%) | 11 (6.2%) | |
| Nonhematologic | |||
| Fatigue | 0.839 | ||
| No | 64 (95.5%) | 167 (93.8%) | |
| Yes | 3 (4.5%) | 11 (6.2%) | |
| Nausea | 0.614 | ||
| No | 64 (95.5%) | 174 (97.8%) | |
| Yes | 3 (4.5%) | 4 (2.2%) | |
| Vomiting | 0.896 | ||
| No | 66 (98.5%) | 173 (97.2%) | |
| Yes | 1 (1.5%) | 5 (2.8%) | |
| Rash | 1.000 | ||
| No | 64 (95.5%) | 170 (95.5%) | |
| Yes | 3 (4.5%) | 8 (4.5%) | |
| Diarrhea | 0.893 | ||
| No | 65 (97.0%) | 175 (98.3%) | |
| Yes | 2 (3.0%) | 3 (1.7%) | |
| Anorexia | 1.000 | ||
| No | 64 (95.5%) | 170 (95.5%) | |
| Yes | 3 (4.5%) | 8 (4.5%) | |
| Bilirubin | 0.085 | ||
| No | 63 (94.0%) | 176 (98.9%) | |
| Yes | 4 (6.0%) | 2 (1.1%) | |
| ALT/AST | 1.000 | ||
| No | 66 (98.5%) | 175 (98.3%) | |
| Yes | 1 (1.5%) | 3 (1.7%) | |
| Hand-foot syndrome | 0.611 | ||
| No | 66 (98.5%) | 178 (100.0%) | |
| Yes | 1 (1.5%) | 0 (0.0%) | |
| Oral mucositis | 0.085 | ||
| No | 63 (94.0%) | 176 (98.9%) | |
| Yes | 4 (6.0%) | 2 (1.1%) | |
| Peripheral neuropathy | 0.135 | ||
| No | 67 (100.0%) | 169 (94.9%) | |
| Yes | 0 (0.0%) | 9 (5.1%) | |