Characteristics of VV and other OVs
| Virus | VV | Adenovirus | Herpes simplex virus | Coxsackievirus |
|---|---|---|---|---|
| Genome | dsDNA(∼200 kb) | dsDNA(30–40 kb) | dsDNA(∼152 kb) | (+)ssRNA(∼7.4 kb) |
| Genome capacity | 25–40 kb | 7–8 kb | 30–40 kb | 300 bases |
| Cell entry mechanism | Membrane penetration and fusion | Endocytosis | Endocytosis; penetration | Micropinocytosis |
| Replication site | Cytoplasm | Nucleus | Nucleus | Cytoplasm |
| Risk of integration | No | More risk | More risk | No |
| Immunogenicity | High | Low | Low | Low |