Oncolytic vaccinia virus strains and mutations studied for cancer treatment
| Strain | Modification | Representative viruses | Insertions (Ref) |
|---|---|---|---|
| Wyeth | J2R- | Pexa-vec | GM-CSF45 |
| WR | J2R-, VGF- | vvDD | GFP46 |
| Lister | J2R-, F14.5L-, A56R- | GL-ONC1 | Renilla luciferase-GFP fusion protein, β-galactosidase, β-glucuronidase74 |
| VGF-, O1L- | ASP9801 | IL-7/IL1257 | |
| Tian Tan Guang 9 | J2R- | VG9 | GM-CSF; IL-2495 |
| Copenhagen | J2R-, I4L- | TG-6002 | FCU-123 |
| New York City Board of Health | 5p, 3p, and B14R | vaccinia virus-aCEA TCE | aCEA T cell engagers29 |