Table 1

Overview the roles of lncRNAs in regulating PD-L1 expression

LncRNACancer typesRegulated targetsMechanismsReference
MALAT1DLBCLmiR-195MALAT1 sponges miR-195 to promote PD-L1 expression7
EMX2OSOCmiR-654EMX2OS interacts with miR-654 to increase PD-L1 expression7
MIR17HGCRCmiR-375MIR17HG induces PD-L1 expression via sponging miR-3757
GATA3-AS1BCmiR-676-3p/COPS5GATA3-AS1 increases PD-L1 expression by regulating the miR-676-3p/COPS5 pathway7
KCNQ1OT1PCmiR-15aKCNQ1OT1 activates PD-L1 expression through binding to and inactivating miR-15a7
MALAT1LADmiR-200a-3pMALAT1 increases PD-L1 expression by sponging miR-200a-3p7
FGD5-AS1LADmiR-142LncRNA FGD5-AS1 acts as a sponge of miR-142 to regulate PD-L1 expression7
LINC00473PCmiR-195-5pLINC00473 enhances PD-L1 expression by binding to miR-195-5p7
KCNQ1OT1HCCmiR-506KCNQ1OT1 interacts with miR-506 to promote PD-L1 expression7
PCED1B-AS1HCCmiR-194-5pPCED1B-AS1 enhances PD-L1 expression through binding to miR-194-5p7
Lnc-OC1ECmiR-34aLnc-OC1 enhances PD-L1 expression by sponging miR-34a7
MEG3ECmiR-216aMEG3 upregulates PD-L1 expression by targeting miR-216a7
SNHG15GCmiR-141SNHG15 increases PD-L1 expression by targeting miR-1417
HIF1A-AS2GCmiR-429HIF1A-AS2 contributes PD-L1 expression through binding to miR-4297
NUTM2A-AS1GCmiR-376aNUTM2A-AS1 enhances PD-L1 expression by sponging miR-376a7
CASC11HCCNF-κBCASC11 activates NF-κB to further increase PD-L1 expression8
XISTHCCmiR-194-5p/miR-155-5pXIST promotes PD-L1 expression via targeting miR-194-5p and miR-155-5p8
PMSB8-AS1PCSTAT1PMSB8-AS1 increases STAT1 expression to further promote PD-L1 expression8
NKX2-1-AS1LADNKX2-1NKX2-1-AS1 inhibits PD-L1 expression through modulating NKX2-1 expression8
ZFPM2-AS1LADJAK-STAT/AKTZFPM2-AS1 increases PD-L1 expression via regulating JAK-STAT/AKT pathways8
LncAMPCPCmiR-637LncAMPC acts as a sponge of miR-637 to regulate PD-L1 expression8
INCR1ThyHNRNPH1Binding between INCR1 and HNRNPH1 suppresses PD-L1 expression8
LncMX1-215HNSCCGCN5LncMX1-215 negatively regulates PD-L1 expression by suppressing H3K27 acetylation via binding to GCN58
AFAP1-AS1NPCmiR-519AFAP1-AS1 upregulates PD-L1 expression via directly targeting miR-5198
SNHG20ESCCATM/JAKSNHG20 regulates PD-L1 expression through modulation of the ATM/JAK pathway8
UCA1ATCmiR-148aUCA1 interacts with miR-148a to promote PD-L1 expression8

DLBCL, diffuse large B cell lymphoma; OC, ovarian cancer; EC, endometrial cancer; GC, gastric cancer; HCC, hepatocellular carcinoma; PC, pancreatic cancer; LAD, lung adenocarcinoma; BC, breast cancer; Thy, thymoma; HNSCC, head and neck squamous cell carcinoma; NPC, nasopharyngeal carcinoma; ESCC, esophageal squamous cell carcinoma; ATC, anaplastic thyroid carcinoma; CRC, colorectal cancer.