Table 3

Overview of the lncRNA role in regulating adaptive cells in the TIME

LncRNACancer typesImmune cellsRegulated targetsMechanismsReference
MALAT1LADTh1/Th2miR-155MALAT1 interacts with miR-155 to increase the Th1:Th2 ratio12
NEAT1Th17 cellsSTAT3NEAT1 inhibits STAT3 expression to suppress CD4+ T cell differentiation into Th17 cells12
FIRREDLBCLB cellsWnt/β-CateninFIRRE promotes DLBCL proliferation by regulating the Wnt/β-catenin signaling pathway12
GAS5DLBCLB cellsmiR-222GAS5 interacts with miR-222 to promote DLBCL apoptosis12
CRNDEBCP-ALLB cellsmiR-345-5pCRNDE reduces BCP-ALL apoptosis via sponging miR-345-5p12
FENDRRHCCTregGADD45BFENDRR increases GADD45B expression to inhibit Treg-mediated immune escape15
SNHG1BCTregmiR-448/IDOSNHG1 contributes to Treg differentiation and promotes cancer cell immune evasion via the miR-448/IDO signaling pathway15
POU3F3GCTregTGF-βPOU3F3 promotes Treg distribution by activating TGF-β signaling pathway15
RP11-323N12.5GCTregYAPRP11-323N12.5 induces Treg differentiation by enhancing YAP transcription15
NEAT1HCCCD8+T cellsmiR-155/Tim-3NEAT1 enhances CD8+T cell apoptosis by regulating the miR-155/Tim-3 signaling pathway15
Lnc-TIM3HCCCD8+T cellsTim-3Lnc-TIM3 interacts with Tim3 to suppress NFAT1 and AP-1, thus leading to CD8+ T cell exhaustion15
Lnc-Sox5CRCCD8+T cellsIDO1Lnc-Sox5 promotes IDO1 expression to inhibit CD8+ T cell infiltration15

HCC, hepatocellular carcinoma; CRC, colorectal cancer; LAD, lung adenocarcinoma; BC, breast cancer; GC, gastric cancer; DLBCL, diffuse large B cell lymphoma; BCP-ALL, B-cell precursor acute lymphoblastic leukemia; Th1, T helper type 1; Th2, T helper type 2; Th17, T helper type 17; Treg, T regulatory cell.