Table 3

Overview of the lncRNA role in regulating adaptive cells in the TIME

LncRNA	Cancer types	Immune cells	Regulated targets	Mechanisms	Reference
MALAT1	LAD	Th1/Th2	miR-155	MALAT1 interacts with miR-155 to increase the Th1:Th2 ratio	¹²
NEAT1	—	Th17 cells	STAT3	NEAT1 inhibits STAT3 expression to suppress CD4+ T cell differentiation into Th17 cells	¹²
FIRRE	DLBCL	B cells	Wnt/β-Catenin	FIRRE promotes DLBCL proliferation by regulating the Wnt/β-catenin signaling pathway	¹²
GAS5	DLBCL	B cells	miR-222	GAS5 interacts with miR-222 to promote DLBCL apoptosis	¹²
CRNDE	BCP-ALL	B cells	miR-345-5p	CRNDE reduces BCP-ALL apoptosis via sponging miR-345-5p	¹²
FENDRR	HCC	Treg	GADD45B	FENDRR increases GADD45B expression to inhibit Treg-mediated immune escape	¹⁵
SNHG1	BC	Treg	miR-448/IDO	SNHG1 contributes to Treg differentiation and promotes cancer cell immune evasion via the miR-448/IDO signaling pathway	¹⁵
POU3F3	GC	Treg	TGF-β	POU3F3 promotes Treg distribution by activating TGF-β signaling pathway	¹⁵
RP11-323N12.5	GC	Treg	YAP	RP11-323N12.5 induces Treg differentiation by enhancing YAP transcription	¹⁵
NEAT1	HCC	CD8+T cells	miR-155/Tim-3	NEAT1 enhances CD8+T cell apoptosis by regulating the miR-155/Tim-3 signaling pathway	¹⁵
Lnc-TIM3	HCC	CD8+T cells	Tim-3	Lnc-TIM3 interacts with Tim3 to suppress NFAT1 and AP-1, thus leading to CD8+ T cell exhaustion	¹⁵
Lnc-Sox5	CRC	CD8+T cells	IDO1	Lnc-Sox5 promotes IDO1 expression to inhibit CD8+ T cell infiltration	¹⁵

HCC, hepatocellular carcinoma; CRC, colorectal cancer; LAD, lung adenocarcinoma; BC, breast cancer; GC, gastric cancer; DLBCL, diffuse large B cell lymphoma; BCP-ALL, B-cell precursor acute lymphoblastic leukemia; Th1, T helper type 1; Th2, T helper type 2; Th17, T helper type 17; Treg, T regulatory cell.