Multi-omics research on gastric inflammation-induced tumorigenesis
| Omics level | Omics conducted | Sample categories | Study design | Highlighted findings | Refs |
|---|---|---|---|---|---|
| Phenotype | Phenomics | Clinical follow-up information | Longitudinal | Association between smoking and IM progression | 47 |
| Phenotype | Phenomics | Tissue samples and PBMC | Longitudinal | Association between serum biomarkers and gastric precancerous progression | 48 |
| Cellular | Single-cell transcriptomics | Tissue samples | Cross-sectional | Single-cell atlas, cell cluster marker, GC signatures | 33 |
| Cellular | Single-cell transcriptomics | Tissue samples and PBMC | Cross-sectional | TME components, receptor‒ligand network | 34 |
| Cellular | Single-cell transcriptomics | Tissue samples | Cross-sectional | Heterogeneous cell population, epithelial-myofibroblast transition | 49 |
| Cellular | Single-cell transcriptomics, spatial transcriptomics | Tissue samples, in vitro and in vivo models | Cross-sectional | Lineage states across GC subtypes | 35 |
| Cellular | Single-cell transcriptomics | Ascites samples | Cross-sectional | Diversity in tumor cell lineage composition, intertumoral heterogeneity | 36 |
| Molecular | Genomics | Tissue samples | Cross-sectional | Genomic amplification in GC | 37 |
| Molecular | Genomics | Cell lines | Cross-sectional | Transcription factors and their role in tumorigenesis | 38 |
| Molecular | Genomics | Tissue samples | Cross-sectional | Molecular subtypes of GC | 39 |
| Molecular | Genomics | Tissue samples | Cross-sectional | Association between genetic instability and HP infection | 40 |
| Molecular | Genomics, epigenomics | Tissue samples | Longitudinal | Molecular features of IM progression | 50 |
| Molecular | Microbiomics | Tongue-coating samples | Cross-sectional | Association between the variation in tongue-coating microbiota and development of gastritis | 20 |