Table 4

Network pharmacology research on TCM interventions for gastric inflammation-induced tumorigenesis

Formula	Lesion	Research strategy	Mechanism of action	Refs
Huangqi Jianzhong Tang	CAG	Network pharmacology and metabolomics	Mitochondrial energy metabolism regulation	¹⁰⁸
Qilianshupi decoction	CAG	Network pharmacology and in vivo validation	Survivin and p53 inhibition; regulation of telomerase activity and telomere length	¹⁰⁹
Modified Sijunzi decoction	CAG	Network pharmacology and clinical trial	T-cell receptor beta regulation	¹¹⁰
Huazhuojiedu decoction	CAG	Network pharmacology and in vivo validation	Cancer-associated AKT1 pathway inhibition	¹¹¹
Moluodan	CAG	Network pharmacology and in vitro validation	Inhibition of cell proliferation; promotion of cell differentiation and apoptosis; decreased inflammation; increased lipid droplet accumulation	¹⁰⁴
Banxia Xiexin decoction	CAG	Network pharmacology and in vitro dynamic validation	Gastrin and MAPK signaling pathway regulation	¹¹²
Manpixiao decoction	LGD	Network pharmacology and in vivo validation	EGFR-PI3K-Akt-associated EMT pathway downregulation	¹¹³
Weifuchun capsule	CAG	Network pharmacology and omics data and algorithms, and in vitro validation	Inhibition of inflammatory cytokines; regulation of immune cells, such as T cells and macrophages; inflammation inhibition	¹⁰⁷