Number of risk genotypes‡ | Alive (%) | Death (%) | Crude | Adjusted† | ||
---|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |||
0 | 78 (34.7) | 8 (11.0) | 1.00 (reference) | – | 1.00 (reference) | – |
1 | 87 (38.7) | 30 (41.1) | 2.94 (1.35–6.41) | 0.007 | 3.32 (1.51–7.27) | 0.003 |
2 | 53 (23.6) | 26 (35.6) | 4.21 (1.91–9.31) | < 0.001 | 4.66 (2.08–10.47) | < 0.001 |
3 | 7 (3.1) | 9 (12.3) | 8.77 (3.38–22.77) | < 0.001 | 10.62 (4.04–27.93) | < 0.001 |
P-value for trend | < 0.001 | < 0.001 | ||||
≥ 2 of risk genotypes | 60 (26.7) | 35 (47.9) | 4.86 (2.25–10.48) | < 0.001 | 5.57 (2.55–12.16) | < 0.001 |
HR, hazard ratio; CI, confidence interval. †Adjusted for gender, age, clinical stage, tumor grade, KPS, surgical procedure, and tumor location. ‡Risk genotypes were CASP4 rs571407 TT, ALOX5 rs2242332 CC, and HO-1 rs17883419 CT + TT.