Relationships between CASP4 SNP haplotypes and OS of rectal cancer patients with postoperative CRT
| Haplotypes | A | B | C | D | Total (%) | Alive (%) | Death (%) | Crude | Adjusted† | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||||||||
| H1 | C | T | A | T | 41.5 | 37.5 | 53.2 | 1.00 (reference) | – | 1.00 (reference) | – |
| H2 | C | C | G | C | 19.5 | 20.1 | 17.6 | 0.58 (0.34–0.98) | 0.043 | 0.52 (0.30–0.92) | 0.026 |
| H3 | T | C | G | C | 16.8 | 17.6 | 14.1 | 0.54 (0.30–0.95) | 0.033 | 0.50 (0.27–0.92) | 0.027 |
| H4 | T | C | A | T | 4.3 | 5.1 | 2.1 | 0.27 (0.08–0.97) | 0.046 | 0.27 (0.07–1.03) | 0.057 |
| H5 | C | T | A | C | 9.5 | 9.9 | 8.2 | 0.53 (0.27–1.07) | 0.077 | 0.57 (0.27–1.21) | 0.146 |
| H6 | C | T | G | C | 5.1 | 5.8 | 3.4 | 0.45 (0.16–1.23) | 0.121 | 0.47 (0.16–1.37) | 0.169 |
| H7 | C | C | A | T | 1.6 | 2.2 | 0.0 | – | – | – | – |
| Rare‡ | – | – | – | – | – | – | – | – | – | – | – |
HR, hazard ratio; CI, confidence interval; A, rs543923; B, rs571407; C, rs623114; D, rs612987. †Adjusted for gender, age, clinical stage, tumor grade, KPS, surgical procedure, and tumor location. ‡Rare: Haplotypes with frequencies < 1%.