Relationships between 16 significant genetic variations and OS of rectal cancer patients in co-dominant and dominant models
| Genotype | Alive (%) | Death (%) | Crude | Adjusted† | ||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| rs113420705‡ | ||||||
| CC | 103 (46.2) | 25 (34.2) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 95 (42.6) | 34 (46.6) | 1.41 (0.84–2.37) | 0.191 | 1.46 (0.87–2.48) | 0.154 |
| TT | 25 (11.2) | 14 (19.2) | 2.11 (1.09–4.06) | 0.026 | 2.41 (1.21–4.78) | 0.012 |
| CT + TT | 120 (53.8) | 48 (65.8) | 1.56 (0.96–2.53) | 0.071 | 1.64 (1.00–2.68) | 0.050 |
| rs4647700 | ||||||
| GAG-GAG | 170 (75.2) | 49 (66.2) | 1.00 (reference) | – | 1.00 (reference) | – |
| GAG-del | 54 (23.9) | 20 (27.0) | 1.28 (0.76–2.15) | 0.355 | 1.24 (0.73–2.11) | 0.422 |
| del-del | 2 (0.9) | 5 (6.8) | 4.11 (1.62–10.41) | 0.003 | 3.53 (1.33–9.34) | 0.011 |
| GAG-del + del-del | 56 (24.8) | 25 (33.8) | 1.48 (0.91–2.40) | 0.110 | 1.42 (0.87–2.33) | 0.162 |
| rs12263370‡ | ||||||
| GG | 167 (75.2) | 49 (66.2) | 1.00 (reference) | – | 1.00 (reference) | – |
| GA | 53 (23.9) | 18 (24.3) | 1.17 (0.68–2.02) | 0.560 | 1.33 (0.76–2.33) | 0.312 |
| AA | 2 (0.9) | 7 (9.5) | 5.68 (2.55–12.67) | < 0.001 | 4.92 (2.12–11.39) | < 0.001 |
| GA + AA | 55 (24.8) | 25 (33.8) | 1.51 (0.93–2.44) | 0.096 | 1.69 (1.03–2.78) | 0.039 |
| rs11784599 | ||||||
| CC | 156 (69.0) | 59 (79.7) | 1.00 (reference) | – | 1.00 (reference) | – |
| CA | 62 (27.4) | 12 (16.2) | 0.54 (0.29–1.00) | 0.051 | 0.48 (0.25–0.91) | 0.024 |
| AA | 8 (3.6) | 3 (4.1) | 0.90 (0.28–2.88) | 0.864 | 0.64 (0.20–2.12) | 0.468 |
| CA + AA | 70 (31.0) | 15 (20.3) | 0.59 (0.33–1.03) | 0.065 | 0.51 (0.28–0.91) | 0.022 |
| rs571407 | ||||||
| TT | 60 (26.5) | 33 (44.6) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 122 (54.0) | 31 (41.9) | 0.50 (0.31–0.82) | 0.006 | 0.46 (0.28–0.75) | 0.002 |
| CC | 44 (19.5) | 10 (13.5) | 0.44 (0.22–0.89) | 0.022 | 0.39 (0.19–0.82) | 0.012 |
| CT + CC | 166 (73.5) | 41 (55.4) | 0.49 (0.31–0.77) | 0.002 | 0.44 (0.28–0.70) | 0.001 |
| rs612987 | ||||||
| TT | 45 (19.9) | 23 (31.1) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 118 (52.2) | 37 (50.0) | 0.63 (0.37–1.06) | 0.083 | 0.56 (0.33–0.96) | 0.034 |
| CC | 63 (27.9) | 14 (18.9) | 0.46 (0.24–0.89) | 0.022 | 0.45 (0.23–0.88) | 0.020 |
| CT + CC | 181 (80.1) | 51 (68.9) | 0.57 (0.35–0.94) | 0.026 | 0.52 (0.32–0.87) | 0.013 |
| rs623114 | ||||||
| AA | 69 (30.5) | 32 (43.2) | 1.00 (reference) | – | 1.00 (reference) | – |
| GA | 114 (50.5) | 31 (41.9) | 0.57 (0.35–0.94) | 0.028 | 0.52 (0.31–0.86) | 0.010 |
| GG | 43 (19.0) | 11 (14.9) | 0.56 (0.28–1.11) | 0.098 | 0.49 (0.24–0.99) | 0.046 |
| GA + GG | 157 (69.5) | 42 (56.8) | 0.57 (0.36–0.90) | 0.017 | 0.51 (0.32–0.82) | 0.005 |
| rs543923‡ | ||||||
| CC | 135 (60.0) | 53 (71.6) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 78 (34.7) | 18 (24.3) | 0.60 (0.35–1.03) | 0.062 | 0.55 (0.32–0.94) | 0.031 |
| TT | 12 (5.3) | 3 (4.1) | 0.59 (0.18–1.89) | 0.374 | 0.52 (0.15–1.73) | 0.286 |
| CT + TT | 90 (40.0) | 21 (28.4) | 0.60 (0.36–0.99) | 0.047 | 0.54 (0.32–0.91) | 0.022 |
| rs2954558 | ||||||
| CC | 158 (69.9) | 44 (59.5) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 59 (26.1) | 24 (32.4) | 1.36 (0.83–2.24) | 0.226 | 1.55 (0.93–2.59) | 0.092 |
| TT | 9 (4.0) | 6 (8.1) | 2.11 (0.90–4.96) | 0.086 | 2.27 (0.93–5.51) | 0.071 |
| CT + TT | 68 (30.1) | 30 (40.5) | 1.46 (0.92–2.33) | 0.107 | 1.66 (1.03–2.67) | 0.037 |
| rs702365‡ | ||||||
| GG | 81 (36.0) | 38 (51.4) | 1.00 (reference) | – | 1.00 (reference) | – |
| GC | 105 (46.7) | 28 (37.8) | 0.60 (0.37–0.97) | 0.038 | 0.60 (0.37–0.98) | 0.041 |
| CC | 39 (17.3) | 8 (10.8) | 0.49 (0.23–1.04) | 0.063 | 0.52 (0.24–1.12) | 0.094 |
| GC + CC | 144 (64.0) | 36 (48.6) | 0.57 (0.36–0.90) | 0.015 | 0.58 (0.37–0.92) | 0.020 |
| rs2242332 | ||||||
| CC | 112 (49.6) | 50 (67.6) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 96 (42.4) | 20 (27.0) | 0.50 (0.30–0.84) | 0.009 | 0.47 (0.27–0.79) | 0.005 |
| TT | 18 (8.0) | 4 (5.4) | 0.54 (0.20–1.50) | 0.240 | 0.56 (0.20–1.59) | 0.278 |
| CT + TT | 114 (50.4) | 24 (32.4) | 0.51 (0.31–0.82) | 0.006 | 0.48 (0.29–0.79) | 0.004 |
| rs4948673‡ | ||||||
| TT | 133 (59.1) | 56 (75.7) | 1.00 (reference) | – | 1.00 (reference) | – |
| TA | 83 (36.9) | 16 (21.6) | 0.49 (0.28–0.86) | 0.013 | 0.49 (0.28–0.86) | 0.013 |
| AA | 9 (4.0) | 2 (2.7) | 0.55 (0.13–2.25) | 0.406 | 0.51 (0.12–2.14) | 0.354 |
| TA + AA | 92 (40.9) | 18 (24.3) | 0.50 (0.29–0.85) | 0.010 | 0.49 (0.28–0.84) | 0.010 |
| rs36207883‡ | ||||||
| GG | 66 (30.4) | 28 (40.0) | 1.00 (reference) | – | 1.00 (reference) | – |
| GA | 111 (51.2) | 36 (51.4) | 0.85 (0.52–1.39) | 0.513 | 0.66 (0.40–1.10) | 0.114 |
| AA | 40 (18.4) | 6 (8.6) | 0.44 (0.18–1.07) | 0.069 | 0.38 (0.16–0.93) | 0.035 |
| GA + AA | 151 (69.6) | 42 (60.0) | 0.75 (0.46–1.21) | 0.237 | 0.60 (0.37–0.98) | 0.041 |
| rs17883419‡ | ||||||
| CC | 182 (80.9) | 46 (63.0) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 38 (16.9) | 23 (31.5) | 2.09 (1.26–3.44) | 0.004 | 2.29 (1.38–3.82) | 0.001 |
| TT | 5 (2.2) | 4 (5.5) | 2.42 (0.87–6.74) | 0.090 | 2.16 (0.76–6.14) | 0.150 |
| CT + TT | 43 (19.1) | 27 (37.0) | 2.13 (1.32–3.43) | 0.002 | 2.27 (1.40–3.69) | 0.001 |
| rs2071749 | ||||||
| GG | 115 (50.9) | 51 (68.9) | 1.00 (reference) | – | 1.00 (reference) | – |
| GA | 96 (42.5) | 21 (28.4) | 0.56 (0.34–0.93) | 0.024 | 0.57 (0.34–0.96) | 0.036 |
| AA | 15 (6.6) | 2 (2.7) | 0.34 (0.08–1.41) | 0.139 | 0.27 (0.06–1.12) | 0.072 |
| GA + AA | 111 (49.1) | 23 (31.1) | 0.53 (0.32–0.87) | 0.011 | 0.52 (0.32–0.87) | 0.012 |
| rs73976300 | ||||||
| CC | 177 (78.3) | 65 (87.8) | 1.00 (reference) | – | 1.00 (reference) | – |
| CT | 47 (20.8) | 8 (10.8) | 0.50 (0.24–1.05) | 0.067 | 0.40 (0.19–0.85) | 0.017 |
| TT | 2 (0.9) | 1 (1.4) | 1.42 (0.20–10.22) | 0.730 | 2.39 (0.31–18.53) | 0.404 |
| CT + TT | 49 (21.7) | 9 (12.2) | 0.54 (0.27–1.09) | 0.085 | 0.44 (0.21–0.91) | 0.026 |
HR, hazard ratio; CI, confidence interval. †Adjusted for gender, age, clinical stage, tumor grade, KPS, surgical procedure, and tumor location. ‡Some samples were not successfully genotyped.