Relationships between ALOX5 SNP haplotypes and OS of rectal cancer patients with postoperative CRT
| Haplotypes | A | B | C | Total (%) | Alive (%) | Death (%) | Crude | Adjusted† | ||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |||||||
| H1 | G | C | T | 61.5 | 58.9 | 69.6 | 1.00 (reference) | – | 1.00 (reference) | – |
| H2 | C | T | A | 19.4 | 21.6 | 12.8 | 0.50 (0.29–0.87) | 0.014 | 0.50 (0.28–0.88) | 0.018 |
| H3 | C | C | T | 11.4 | 11.6 | 10.8 | 0.80 (0.43–1.50) | 0.490 | 0.87 (0.44–1.72) | 0.692 |
| H4 | C | T | T | 6.9 | 7.2 | 6.1 | 0.74 (0.34–1.58) | 0.436 | 0.67 (0.30–1.52) | 0.336 |
| Rare‡ | – | – | – | – | – | – | – | – | – | – |
HR, hazard ratio; CI, confidence interval; A, rs702365; B, rs2242332; C, rs4948673. †Adjusted for gender, age, clinical stage, tumor grade, KPS, surgical procedure, and tumor location. ‡Rare: Haplotypes with frequencies < 1%.