Clinical trials targeting the intercellular transmission of cGAS-STING signaling in cancers
| Elements | Classification | Investigational products | Indications |
|---|---|---|---|
| dsDNA | Extracellular vesicles | Topotecan (U.S. FDA approved) | Lung cancer |
| cGAMP | ENPP1 inhibitor | RBS2418 | Advanced cancer |
| Gap junction inhibitor | Tonabersat, carabersat | Brain metastasis | |
| Transporter activator | Not yet developed | Not yet developed | |
| STING | Extracellular vesicles | Not yet developed | Not yet developed |