Table 2

Univariate and multivariate analyses for malignant transformation based on clinical and molecular variables

Variables		Univariate			Multivariate
Variables		n/108	HR	95% CI	P	HR	95% CI	P
Age (19–54, years)	108/108	1.011	0.989–1.033	0.348	1.000	0.962–1.040	0.997
Gender
Male vs. female	108/108	1.161	0.781–1.725	0.461	1.347	0.740–2.453	0.330
Grade	96/108
3 vs. 2	74 vs. 22	1.420	0.879–2.295	0.152	1.645	0.877–3.089	0.121
Location 1	108/108
Left vs. right	45 vs. 63	1.099	0.750–1.611	0.627	1.300	0.703–2.405	0.403
Location 2	107/108
Single vs. multiple lobe	75 vs. 32	0.721	0.473–1.099	0.128	0.552	0.229–1.019	0.058
Radiotherapy	102/108
Yes vs. no	78 vs. 24	0.499	0.313–0.795	0.003	0.285	0.137–0.595	0.001
Chemotherapy	97/108
Yes vs. no	41 vs. 56	1.093	0.726–1.645	0.670	1.540	0.860–2.757	0.146
Blood type	95/108
B/O vs. A/AB	39 vs. 56	0.589	0.385–0.903	0.015	0.372	0.203–0.680	0.001
MGMT promoter methylation	90/108
Yes vs. no	65 vs. 25	0.979	0.663–1.446	0.914	0.596	0.653–2.101	0.596
1p/19q co-deletion	94/108
Yes vs. no	15 vs.79	0.648	0.363–1.155	0.141	0.788	0.387–1.603	0.511