Table 2

Characteristics of primary diffuse gliomas

	n	LGG, IDH-mutant and 1p/19q-codeleted	LGG, IDH-mutant	LGG, IDH-wildtype	GBM, IDH-wildtype	GBM, IDH-mutant	P	LGG NOS	GBM NOS
Sex	946	130	130	103	248	63	0.7995	236	36
Male	541	72	75	59	150	40	0.7995	123	22
Female	405	58	55	44	98	23		113	14
Age
≥ 45	460	56	37	34	195	28	< 0.0001	83	27
< 45	486	74	93	69	53	35		153	9
Mean age, years	44.30	42.15	39.15	38.55	52.86	43.67		41.17	49.75
SD of age	12.73	9.89	8.57	16.04	12.57	11.79		9.98	11.57
Karnofsky performance status
≥ 80	857	126	123	100	233	58	0.3722	189	28
< 80	30	4	3	2	14	2		4	1
Diagnostic symptom	890	130	127	102	247	62	< 0.0001	193	29
Headache	445	49	56	48	156	43		77	16
Seizure	331	68	64	40	37	18		95	9
Neurofunction deficit	240	22	19	29	114	12		35	9
No clear symptom	58	15	6	8	5	1		22	1
Lateral involved	935	130	129	101	244	63	0.0408	233	35
Right	450	66	66	44	110	29		114	21
Left	439	57	57	46	123	32		113	11
Both sides	43	7	6	8	11	2		6	3
Midline	3	0	0	3	0	0		0	0
Cortex involved (n)	935	130	129	101	244	63	< 0.0001	233	35
Frontal lobe	607	103	93	51	114	43		181	22
Temporal lobe	386	40	50	40	118	32		92	14
Insular lobe	237	34	44	21	46	16		73	3
Parietal lobe	183	17	21	22	67	11		34	11
Occipital lobe	77	1	5	7	45	5		13	1
Other lobes	50	6	6	10	19	3		6	0