Table 1

Distribution of 1418 cases of diffuse glioma according to clinicopathological information

Characteristics	Diffuse glioma	Primary diffuse glioma	Recurrent diffuse glioma	P
Sex
Male	839	541	298	0.0339
Female	579	405	174
Age
≥ 45	659	460	200	0.0276
< 45	755	486	272
Mean age, years (SD)	43.55 (12.33)	44.33 (12.95)	42.00 (10.67)
Symptom at onset (n = 1334)
Headache	555	445	110	< 0.0001
Seizure	457	331	126
Focal deficit	393	240	153
No clear symptoms	179	58	121
Karnofsky performance status (n = 1330)
≥ 80	1260	857	403	< 0.0001
< 80	70	30	40
Lateral involvement (n = 1390)
Right	656	450	206	0.6024
Left	659	439	220
Both sides	70	43	27
Midline	5	3	2
Cortex involvement (n = 1390)
Frontal lobe	931	607	324	0.0017
Temporal lobe	586	386	200
Insular lobe	309	237	72
Parietal lobe	298	183	115
Occipital lobe	120	77	43
Other lobes	72	50	22
Histological grade
II	376	309	67	< 0.0001
III	413	290	123
IV	629	347	282
Molecular subtype
LGG, IDH-mutant and 1p/19q-codeleted	167	130	37	< 0.0001
LGG, IDH-mutant	195	130	65
LGG, IDH-wildtype	141	103	38
LGG, NOS	286	236	50
GBM, IDH-wildtype	389	248	141
GBM, IDH-mutant	185	63	122
GBM, NOS	55	36	19
MGMT methylation (n = 1080)
Unmethylated	374	251	123	0.4077
Methylated	706	492	214
Types of surgery
Total resection	627	475	152	< 0.0001
Subtotal resection	511	333	178
Partial resection	278	138	140
Biopsy	2	0	2
Treatment (n = 1274)
Radio chemotherapy	643	520	123	< 0.0001
Radiotherapy	173	151	22
Chemotherapy	263	74	189
None	195	111	84