Table 1

Clinical drugs and pre-clinical compounds that activate pyroptosis in cancer cells

Name of drugTarget proteinGasderminCell typesDaily useReference
Docosahexaenoic acidNLRP3GSDMDBreast cancerNutrient96,97
CisplatinCaspase-3GSDMELung cancer, esophageal squamous cell carcinomaChemotherapy98,88
PaclitaxelCaspase-3GSDMELung cancerChemotherapy98
As2O3NLRP1, 3GSDMEHepatocellular carcinomaChemotherapy99
IronTom20GSDMEMelanomaAnti-anemia100
DoxorubicineEF-2KGSDMEMelanomaChemotherapy101
PyridoxineCaspase-3GSDMEleukemiaNutrient102
LobaplatinJNKGSDMEColon cancerChemotherapy103
MetforminPELP1GSDMDEsophageal carcinomaAnti-diabetes104
AnthocyaninNLRP3GSDMDOral squamous cell carcinomaNutrient105
DPP 8/9 inhibitorsNLRP1, CARD8GSDMDLeukemia-106,107
FL118NLRP3GSDMDColorectal cancer-108
α-NETAPro-caspase-4GSDMDEpithelial ovarian cancer-109
L61H10Caspase-3GSDMELung cancer-110
MiltironeMEK, ERKGSDMEHepatocellular carcinoma-111