Figure 3

Correlation between DNA damage response and repair (DDR) gene mutations and the tumor microenvironment. (A–D) The tumor mutation burden between patients with ≥ 2 DDR gene mutations and < 2 DDR gene mutations in the MSK-GI cohort (A), the Janjigian cohort (B), the PUCH cohort (C) and TCGA-GI cancer cohort (D). (E) The number of neoantigens comparing patients with ≥ 2 DDR gene mutations and < 2 from TCGA database. (F) Comparison of the immune cell infiltration between the ≥ 2 and < 2 DDR gene mutation subgroups in the analysis of GI cancers. (G) Heat map showing the differentially expressed immune signatures between the subgroup of patients with ≥ 2 DDR gene mutations and the subgroup with < 2 DDR gene mutations in TCGA. GI, gastrointestinal; TMB, tumor mutation burden; GEP, gene expression profile; T_eff, effector T cell; TLS, tertiary lymphoid structures; EC, esophageal cancer; GC, gastric cancer; CRC, colorectal cancer.