Demographic and clinicopathological features of LS and sporadic CRCs
| Parameters | Total, n (%) n = 628 | LS, n (%) n = 88 | Sporadic, n (%) n = 540 | P value |
|---|---|---|---|---|
| Gender | 0.48 | |||
| Male | 362 (57.9%) | 54 (61.4%) | 308 (57.4%) | |
| Female | 263 (42.1%) | 34 (38.6%) | 229 (42.6%) | |
| Age (years) | <0.001 | |||
| Median (range) | 59 (22–86) | 53 (22–71) | 60 (23–86) | |
| <55 | 250 (39.8%) | 53 (60.2%) | 197 (36.5%) | |
| ≥55 | 378 (60.2%) | 35 (39.8%) | 343 (63.5%) | |
| Clinical stage | 0.001 | |||
| I | 55 (9.6%) | 11 (13.6%) | 44 (8.9%) | |
| II | 282 (49.2%) | 53 (65.4%) | 229 (46.5%) | |
| III | 203 (35.4%) | 15 (18.5%) | 188 (38.2%) | |
| IV | 33 (5.8%) | 2 (2.5%) | 31 (6.3%) | |
| Location | <0.001 | |||
| Left | 321 (56.6%) | 26 (32.5%) | 295 (60.6%) | |
| Right | 246 (43.4%) | 54 (67.5%) | 192 (39.4%) | |
| Differentiation | 0.051 | |||
| Low | 114 (22.6%) | 21 (33.3%) | 93 (21.0%) | |
| Medium | 369 (73.1%) | 38 (60.3%) | 331 (74.9%) | |
| High | 22 (4.4%) | 4 (6.3%) | 18 (4.1%) | |
| Mucinous | <0.001 | |||
| No | 292 (68.1%) | 10 (33.3%) | 282 (70.7%) | |
| Yes | 137 (31.9%) | 20 (66.7%) | 117 (29.3%) | |
| MSI | <0.001 | |||
| MSI-H | 301 (47.9%) | 80 (90.9%) | 221 (40.9%) | |
| MSI-L | 12 (1.9%) | 1 (1.1%) | 11 (2.0%) | |
| MSS | 315 (50.2%) | 7 (8.0%) | 308 (57.0%) | |
| MMR-IHC | <0.001 | |||
| dMMR | 378 (60.2%) | 87 (98.9%) | 291 (53.9%) | |
| pMMR | 250 (39.8%) | 1 (1.1%) | 249 (46.1%) |
MMR, mismatch repair; dMMR, deficient MMR; pMMR, proficient MMR; MSI, microsatellite instability; MSI-H, MSI-high; MSI-L, MSI-low; MSS, microsatellite stability.