Table 3

Multivariable analysis for PFS and OS in patients receiving R-CHOP/R-CHOP-like regimens

Model and variables	PFS		OS
Model and variables	HR (95% CI)	P value	HR (95% CI)	P value	Score
Model 1
BCL2 alteration (yes vs. no)	2.519 (1.586–4.001)	< 0.001	2.610 (1.391–4.896)	0.003	1 vs. 0
TP53 mutation (yes vs. no)	2.055 (1.334–3.167)	0.001	2.295 (1.263–4.170)	0.006	1 vs. 0
IPI score (3–5 vs. 1–2)	2.479 (1.641–3.746)	< 0.001	4.068 (2.236–7.401)	< 0.001	2 vs. 0
Model 2
BCL2^GA/AMP (yes vs. no)	3.074 (1.801–5.246)	< 0.001	2.586 (1.279–5.232)	0.008	1 vs. 0
TP53 mutation (yes vs. no)	1.901 (1.239–2.918)	0.003	2.138 (1.182–3.870)	0.012	1 vs. 0
IPI score (3–5 vs. 1–2)	2.266 (1.503–3.415)	< 0.001	3.750 (2.067–6.800)	< 0.001	2 vs. 0

Bold indicates significance. PFS, progression-free survival; OS, overall survival; IPI, International Prognostic Index; HR, hazard ratio; CI, confidence interval; GA, gain; AMP, amplification.