Table 6

Genes expression in the key signaling pathway

ClassPathway nameGeneUP/DOWN
VEGFREACTOME_SIGNALING_BY_VEGFAXL, ITPR3UP
PAK3, PRKCADOWN
VEGF2REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATIONITPR3UP
PRKCADOWN
ANGIOGENESISHALLMARK_ANGIOGENESISS100A4, LUM, VCANUP
APOPTOSISREACTOME_APOPTOSISTNFSF10UP
BCL2DOWN
AUTOPHAGYREACTOME_AUTOPHAGYTUBA4AUP
METREACTOME_SIGNALING_BY_METCOL1A1, COL5A3, COL1A2, COL5A1UP
EMTTGF-beta_receptor_signaling_in_EMTCGNDOWN
Drug resistance relatedBIOCARTA_PKC_PATHWAYPRKCADOWN
REACTOME_MAPK_FAMILY_SIGNALING_CASCADESAPBB1IP, FGF16, CAMK2AUP
NEFL, NRG3, PAK3, RASGRF1, NRTNDOWN
REACTOME_PI3K_AKT_SIGNALING_IN_CANCERFFGF16, CD86, RAC2, CD28DUP
NRG3DDOWN
REACTOME_PI3K_CASCADE
REACTOME_PTEN_REGULATION
ST_STAT3_PATHWAY