Table 1

Clinicopathological characteristics of patients with early gastric cancer

VariablesTotal (n = 1,050)LNM (−) (n = 899)LNM (+) (n = 151)P
Age (years)60 (52,67)60 (52,67)58 (50,67)0.262
 < 60512 (48.8%)432 (48.1%)80 (53.0%)
 ≥ 60538 (51.2%)467 (51.9%)71 (47.0%)
Gender0.015*
 Male696 (66.3%)609 (67.7%)87 (57.6%)
 Female354 (33.7%)290 (32.3%)64 (42.4%)
Tumor size (cm)2.0 (1.2,2.5)2.0 (1.0,2.5)2.0 (1.5,3.0)0.002*
 ≤ 2698 (66.5%)614 (68.3%)84 (55.6%)
 > 2352 (33.5%)285 (31.7%)67 (44.4%)
Tumor location0.998
 Upper70 (6.7%)60 (6.7%)10 (6.6%)
 Middle322 (30.7%)276 (30.7%)46 (30.5%)
 Lower658 (62.7%)563 (62.6%)95 (62.9%)
Gross type< 0.001*
 Ulcerated340 (32.4%)264 (29.4%)76 (50.3%)
 Non-ulcerated710 (67.6%)635 (70.6%)75 (49.7%)
Degree of differentiation< 0.001*
 Differentiated382 (36.4%)356 (39.6%)26 (17.2%)
 Undifferentiated668 (63.6%)543 (60.4%)125 (82.8%)
Histopathology< 0.001*
 Tub381 (36.3%)355 (39.5%)26 (17.2%)
 Por490 (46.7%)389 (43.3%)101 (66.9%)
 Sig160 (15.2%)140 (15.6%)20 (13.2%)
 Muc18 (1.7%)14 (1.6%)4 (2.6%)
 Pap1 (0.1%)1 (0.1%)0
Examined lymph node21 (17,29)21 (17,28)23 (18,32)0.017*
Her-2 status0.268
 Negative919 (87.5%)791 (88.0%)128 (84.8%)
 Positive131 (12.5%)108 (12.0%)23 (15.2%)
Depth of tumor invasion< 0.001*
 T1a512 (48.8%)485 (53.9%)27 (17.9%)
 T1b538 (51.2%)414 (46.1%)124 (82.1%)
Lymphovascular invasion84 (8.0%)53 (5.9%)31 (20.5%)< 0.001*
Perineural invasion12 (1.1%)6 (0.7%)6 (4.0%)< 0.001*
Treatments after surgery< 0.001*
 Observation945 (90.0%)899 (100%)46 (30.5%)
 S-160 (5.7%)060 (39.7%)
 Xelox45 (4.3%)045 (29.8%)

*P < 0.05 was considered statistically significant. LNM, lymph node metastasis; Tub, tubular adenocarcinoma; Por, poorly differentiated adenocarcinoma; Sig, signet-ring cell carcinoma; Muc, mucinous adenocarcinoma; Pap, papillary adenocarcinoma; T1a, mucosal invasion; T1b, submucosal invasion.