Table 3

Predictors of irAEs in all patients

Variable	Univariate analysis			Multivariate analysis
Variable	OR	95% CI	P	OR	95% CI	P
Gender	1.76	0.66–4.70	0.262
Age	0.60	0.26–1.35	0.217
ECOG PS	0.42	0.13–1.30	0.160
BMI	0.66	0.29–1.48	0.313
Distant metastasis	0.44	0.19–1.03	0.06
Treatment lines	2.03	0.84–4.94	0.117
RLC (cutoff = 28.5%)	3.32	1.28–8.63	0.014*	3.60	1.16–11.19	0.027*
AEC (cutoff = 0.175 × 10⁹/L)	0.32	0.14–0.76	0.010*	0.29	0.10–0.82	0.020*
PLT (cutoff = 232.5 × 10⁹/L)	2.77	1.14–6.73	0.025*			0.122
ALB (cutoff = 39.05 g/L)	0.25	0.10–0.66	0.005**	0.18	0.55–0.58	0.004**
LDH (cutoff = 214.5 U/L)	0.377	0.147–0.967	0.042*			0.139

*P < 0.05; **P < 0.01. irAEs, immune-related adverse events; ECOG PS, Eastern Cooperative Oncology Group performance status; RLC, relative lymphocyte count; AEC, absolute eosinophil count; PLT, platelet; ALB, albumin; LDH, lactate dehydrogenase.