Univariate and multivariate Cox regression in the entire MSK-IMPACT cohort except the MMR mutant subgroup for the combined 4 DDR gene mutations
| Factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Cancer type | ||||
| Lung cancer | Ref | Ref | ||
| Bladder cancer | 0.77 (0.61–0.99) | 0.037 | 0.82 (0.65–1.1) | 0.118 |
| Breast cancer | 1.4 (0.97–2.1) | 0.071 | 1.3 (0.88–1.9) | 0.202 |
| CNS tumor | 1.2 (0.90–1.5) | 0.265 | 1.0 (0.80–1.3) | 0.785 |
| Esophagogastric cancer | 1.1 (0.83–1.5) | 0.465 | 1.1 (0.80–1.4) | 0.652 |
| Colorectal cancer | 0.81 (0.58–1.1) | 0.240 | 0.86 (0.61–1.2) | 0.405 |
| Head and neck cancer | 1.1 (0.83–1.4) | 0.600 | 1.0 (0.77–1.3) | 0.998 |
| Melanoma | 0.40 (0.32–0.50) | <0.001 | 0.43 (0.34–0.54) | <0.001 |
| Renal cancer | 0.36 (0.27–0.48) | <0.001 | 0.32 (0.24–0.43) | <0.001 |
| Primary unknown | 1.1 (0.78–1.6) | 0.559 | 1.1 (0.75–1.5) | 0.704 |
| TMB | 0.98 (0.97–0.99) | <0.001 | 0.98 (0.97–0.99) | <0.001 |
| ATM/BRCA2/FANCC/RAD50 (wild type) | 1.6 (1.3–2.1) | <0.001 | 1.4 (1.1–1.8) | 0.017 |