Table 2

Maturity classifications of tertiary lymphoid structures

Definition and cellular compositionMarker cell subsets
E-TLSDense lymphocytic aggregates without FDCsCD4+ and CD8+T cells, CD20+B cells, and occasional DCs
PFL-TLSHaving more dense lymphocytic aggregates with FDCs but no GC reactionCD4+ and CD8+T cells, CD20+B cells, and/or occasional DCs, and FDC
SFL-TLSHaving dense lymphocytic aggregates with FDCs and GC reactionBcl6+or Ki67+CD20+B cells, CD38+ and/or CD138+ CD19+B cells