Maturity classifications of tertiary lymphoid structures
| Definition and cellular composition | Marker cell subsets | |
|---|---|---|
| E-TLS | Dense lymphocytic aggregates without FDCs | CD4+ and CD8+T cells, CD20+B cells, and occasional DCs |
| PFL-TLS | Having more dense lymphocytic aggregates with FDCs but no GC reaction | CD4+ and CD8+T cells, CD20+B cells, and/or occasional DCs, and FDC |
| SFL-TLS | Having dense lymphocytic aggregates with FDCs and GC reaction | Bcl6+or Ki67+CD20+B cells, CD38+ and/or CD138+ CD19+B cells |