Table 2

Equivalent therapeutic efficacy between QL1101 and bevacizumab was evaluated for the subgroups after excluding the interference factors.

	PFS (days)				OS (days)
	QL1101^a	Bevacizumab^b	HR (95% CI)^c	P^d	QL1101^a	Bevacizumab^b	HR (95% CI)^c	P^d
Age (years)
< 65	169	147	0.9985 (0.8014–1.244)	< 0.001	Undefined	Undefined	0.9792 (0.6854–1.399	0.0134
≥ 65	131	137	1.288 (0.8777–1.890)	1.673	459	508	1.150 (0.6985–1.894)	0.3025
Gender
Male	150	134	1.065 (0.825–1.374)	0.2321	459	566	1.161 (0.8203–1.643)	0.7084
Female	141	147	1.093 (0.8203–1.456)	0.3687	Undefined	Undefined	0.8216 (0.4839–1.395)	0.5290
Smoking history
Never	150	168	1.130 (0.8807–1.450)	0.9231	Undefined	Undefined	1.032 (0.6695–1.592)	0.0209
Ever	170	133	0.9533 (0.6372–1.426)	0.0541	459	497	1.004 (0.6791–1.484)	< 0.001
Still	130	121	0.9171 (0.5900–1.426)	0.1479	Undefined	396.5	0.6473 (0.3583–1.169)	2.078
Pathology
Wild type	150	144	1.058 (0.8448–1.325)	0.2409	Undefined	566	1.003 (0.7329–1.374)	0.0275
EGFR mutation	142.5	138	1.091 (0.7627–1.561)	0.2286	Undefined	Undefined	1.260 (0.5921–2.682)	0.3602
Tumor history
Yes	146	175	1.602 (0.7613–3.371)	1.541	Undefined	513	0.3735 (0.1200–1.163)	2.888
No	145	140	1.033 (0.8479–1.259)	0.8161	Undefined	Undefined	1.085 (0.8038–1.465)	0.2838
ECOG
0	158	132	0.7639 (0.5121–1.139)	1.744	Undefined	Undefined	1.281 (0.6763–2.426)	0.5772
1	144	154	1.174 (0.9451–1.459)	2.105	Undefined	Undefined	0.9589 (0.6922–1.328)	0.0638

^aBevacizumab biosimilar sourced from Qilu Pharmaceutical Co., Ltd, China. ^bBevacizumab sourced from Roche China. ^cHazard Ratio (95% CI of ratio. ^dChi square value using Mantel-Cox test.