Diagnostic assessment of DNA aneuploidy and modified risk model for 608 OPMD patients recruited from March 2013 to August 2017 constituted the training set
| Group | General OPMD (n = 554) | OPMD concomitant OSCC (n = 54) | Diagnostic accuracy (95% confidence interval) |
|---|---|---|---|
| DI ≥ 3.5 | False positive (n = 104) | True positive (n = 45) | Sensitivity = 83.3% (71.0%–91.2%) |
| DI < 3.5 | True negative (n = 450) | False negative (n = 9) | Specificity = 81.2% (77.8%–84.3%) |
| Risk model (score ≥ 4) | False positive (n = 91) | True positive (n = 52) | Sensitivity = 96.3% (86.7%–99.7%) |
| Risk model (score < 4) | True negative (n = 463) | False negative (n = 2) | Specificity = 83.6% (80.2%–86.4%) |
DI, DNA index; OPMD, oral potentially malignant disorder; OSCC, oral squamous cell carcinoma.