Table 4

Information on 27 genes previously reported to be associated with hyperthermia

GeneTitle of related articlePMID
NFKBIAShort-term hyperthermia prevents activation of proinflammatory genes in fibroblast-like synoviocytes by blocking the activation of the transcription factor NF-kappaB.16955275
CCL20Local hyperthermia decreases the expression of CCL-20 in condyloma acuminatum.21050487
TNFComparative in vitro studies of the potentiation of tumor necrosis factor (TNF)-alpha, TNF-beta, and TNF-SAM2 cytotoxicity by hyperthermia.1571335
GRPRHow gastrin-releasing peptide receptor (GRPR) and α(v)β(3) integrin expression reflect reorganization features of tumors after hyperthermia treatments.28761146
CD44CD44-targeted magnetic nanoparticles kill head and neck squamous cell carcinoma stem cells in an alternating magnetic field.31571863
GDF15Involvement of ERK1/2 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells.20707649
CX3CL1Heat therapy promotes the expression of angiogenic regulators in human skeletal muscle.27357800
ID1Correlation between the expression of Id-1 and hyperthermia-associated molecules in oral squamous cell carcinoma.23723304
GCKCellular signalling after in vivo heat shock in the liver.10772775
CEBPEGene networks involved in apoptosis induced by hyperthermia in human lymphoma U937 cells.19732844
HSPA8P11The cellular and molecular basis of hyperthermia.12098606
TRPV4Ischemic brain injury leads to brain edema via hyperthermia-induced TRPV4 activation.29793978
ADORA1Activation of central adenosine A(2A) receptors lowers the seizure threshold of hyperthermia-induced seizure in childhood rats.21144776
CTGFRole of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers.27806300
COL1A1Molecular pathology of vertebral deformities in hyperthermic Atlantic salmon (Salmo salar).20604915
MEDAGHyperthermia severely affects the vascular effects of MDMA and metabolites in the human internal mammary artery in vitro.28084566
GPC3Glypican-3 (GPC3) targeted Fe3O4 core/Au shell nanocomplex for fluorescence/MRI/photoacoustic imaging-guided tumor photothermal therapy.31603456
FN1Role of CTGF in sensitivity to hyperthermia in ovarian and uterine cancers.27806300
TLR2Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells.17126326
VCANVersican and vascular endothelial growth factor expression levels in peritoneal metastases from colorectal cancer are associated with survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.26873137
MMP2Hyperthermia inhibits the motility of gemcitabine-resistant pancreatic cancer PANC-1 cells through the inhibition of epithelial-mesenchymal transition.29568909
NQO1Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.18283592
H2AFY2Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.30909744
JAM3Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS.19496026
TGIF2Involvement of ERK1/2 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells.20707649
EGFEffect of hyperthermia on invasion ability and TGF-β1 expression of breast carcinoma MCF-7 cells.21455587
NFE2Hyperthermia and protein homeostasis: cytoprotection and cell death.32716865