Summary of adverse events
| Adverse events, n = 40 | All grades, n (%) | Grade 1/2, n (%) | Grade 3/4, n (%) |
|---|---|---|---|
| Myelosuppression (hematology) | 27 (67.5) | 21 (52.5) | 6 (15.0) |
| Leukopenia | 22 (55.0) | 20 (50.0) | 2 (5.0) |
| Neutropenia | 22 (55.0) | 17 (42.5) | 5 (12.5) |
| Thrombocytopenia | 10 (25.0) | 9 (22.5) | 1 (2.5) |
| Decreased hemoglobin | 9 (22.5) | 9 (22.5) | 0 (0) |
| Gastrointestinal reaction | 28 (70.0) | 19 (47.5) | 9 (22.5) |
| Nausea | 23 (57.5) | 22 (55.0) | 1 (2.5) |
| Diarrhea | 19 (47.5) | 13 (32.5) | 6 (15.0) |
| Vomiting | 12 (30.0) | 10 (25.0) | 2 (5.0) |
| Hypertension | 25 (62.5) | 15 (37.5) | 10 (25.0) |
| Pain | 24 (60.0) | 19 (47.5) | 5 (12.5) |
| Malaise | 21 (52.5) | 19 (47.5) | 2 (5.0) |
| Anorexia | 20 (50.0) | 19 (47.5) | 1 (2.5) |
| Elevated transaminase | 19 (47.5) | 19 (47.5) | 0 (0) |
| Hand-foot skin reaction | 19 (47.5) | 16 (40.0) | 3 (7.5) |
| Proteinuria | 15 (37.5) | 14 (35.0) | 1 (2.5) |
| Elevated bilirubin | 13 (32.5) | 12 (30.0) | 1 (2.5) |
| Mucositis | 11 (27.5) | 8 (20.0) | 3 (7.5) |
| Hemorrhage | 8 (20.0) | 7 (17.5) | 1 (2.5) |
| Sinus tachycardia | 6 (15.0) | 6 (15.0) | 0 (0) |
| Elevated creatinine | 3 (7.5) | 3 (7.5) | 0 (0) |