Table 2

DLTs in the phase 1b study

Chidamide dosePatients treated (n)DLT (n)ToxicityBest response
15 mg biw61Grade 3 pulmonary infection2CR, 1PR
20 mg biw161Grade 4 neutropenia with G-CSF support2CR
25 mg biw32Grade 4 neutropenia with G-CSF support2PR

DLT, dose limited toxicity; CR, complete response; PR, partial response; G-CSF, granulocyte colony-stimulating factor.

1Maximum tolerated dose (MTD) and Recommended Phase 2 Dose (RP2D).