CircRNAs modulating the epithelial-mesenchymal transition (EMT) in various carcinomas
| Cancer type | CircRNA | Function | Mechanism | Reference |
|---|---|---|---|---|
| HCC | circCul2 (hsa_circ_10720) | Promoted EMT | Twist1 promoted vimentin expression and EMT by increasing levels of circCul2, which can absorb miRNAs that target vimentin | 31 |
| UCB | circPRMT5 (circRNA_101320) | Promoted EMT and aggressiveness | By circPRMT5/miR-30c/SNAIL1/E-cadherin pathway | 34 |
| Melanoma | circRNA_0084043 | Promoted growth and metastasis | By circRNA_0084043/miR-153-3p/Snail axis | 35 |
| Cervical cancer | circRNA_000284 | Promoted proliferation and cell invasion | By circRNA_000284/miR-506/Snail 2 axis | 36 |
| PTC | circNUP214 (hsa_ circ_0089153) | Promoted proliferation, migration and invasion | By circNUP214/miR-145/ZEB2 axis | 37 |
| TNBC | circANKS1B (hsa_circ_0007294) | Promoted EMT and metastasis | By circANKS1B/miR-152-3p, miR-148a-3p/USF1/TGF-β1/Smad signaling and a positive feedback loop of USF1/circANKS1B | 38 |
| OSCC | circUHRF1 (hsa_circ_0002185) | Promoted proliferation, metastasis, invasion and EMT | By a positive feedback loop of circUHRF1/miR-526b-5p/c-Myc/TGF-β1/ESRP1/circUHRF1 | 39 |
| CRC | circRNA_100290 | Promoted metastasis and EMT | By circRNA_100290/miR-516b/FZD4/Wnt/β-catenin signaling pathway | 40 |
| ccRCC | circAKT3 | Inhibited metastasis and EMT | By circAKT3/miR-296-3p/E-cadherin pathway | 41 |
| DLBCL | circAPC (hsa_circ_0127621) | Hindered cell proliferation | By circAPC/APC/TET1/Wnt/β-catenin signaling pathway | 42 |
| CRC | hsa_circ_0026344 | Functioned as anti-tumor molecule | By hsa_circ_0026344/miR-183/Wnt/β-catenin signaling pathway | 43 |
| Bladder cancer | circPTK2 (hsa_circ_0003221) | Enhanced migration | Unknown | 59 |
| CRC | circPTK2 (hsa_circ_0005273) | Stimulated EMT | Attaching to vimentin protein at sites Ser38, Ser55, Ser82 | 60 |
HCC, hepatocellular carcinoma; UCB, urothelial carcinoma of the bladder; PTC, papillary thyroid cancer; TNBC, triple-negative breast cancer; OSCC, oral squamous cell carcinoma; CRC, colorectal cancer; ccRCC, clear cell renal cell carcinoma; DLBCL, diffuse large B-cell lymphoma.