Characteristics of four subgroups defined by current molecular biomarker profile in Chinese LADC patients

Groups cases defined by molecular biomarkers	Group 1 (n = 258)	Group 2 (n = 29)	Group 3 (n = 41)	Group 4 (n = 100)	P
PD-L1 expression	0	29	41	0
EGFR	252	0	35	0
ALK	6	0	5	0
ROS-1	2	0	1	0
KRAS	0	8	0	26
Age (range, median)	32-80, 60	45-79, 64	32-78, 57	33-83, 62	< 0.001*^a
Gender					< 0.001*^a
Male	102	22	14	49
Female	196	7	27	51
Smoking status					< 0.001*^a
Yes	221	8	12	42
No	77	21	29	58
TNM stage					0.005*^a
I-II	236	25	27	89
III-IV	62	6	16	13
Histopathologic pattern					< 0.001*^b
MIA	11	1	1	5
LPA	41	0	1	11
APA	178	11	25	64
PPA	41	4	3	12
MPP	14	4	0	5
SPA	13	9	11	3
IMA	0	0	0	10

*P<0.05 was considered as significant.

*^a Comparison of Group 3 with other groups. *^b Comparison among groups with significant differences of APA in Group 3&4, MPP in Group 2, SPA in Group 2&3 and IMA in Group 4.

Abbreviations: PD-L1, programmed death-ligand 1; MIA, minimally invasive adenocarcinoma; LPA, lepidic predominant adenocarcinoma; PPA, papillary predominant adenocarcinoma; APA, acinar predominant adenocarcinoma; MPA, micropapillary predominant adenocarcinoma; SPA, solid predominant adenocarcinoma; IMA, invasive mucinous adenocarcinoma.