4

Factors associated with recurrence-free survival

Factors	Univariate			Multiple regression
Factors	HR (95% CI)	P		HR (95% CI)	P
Age (years)	0.632 (0.427, 0.936)	0.022		0.548 (0.348, 0.862)	0.009
< 65	89
= 65	94
Gender	1.512 (1.008, 2.267)	0.046
Male	128
Female	55
Differentiation	0.719 (0.428, 1.325)	0.312
Well/moderately	152
Poorly	31
Comorbidities	0.732 (0.495, 1.083)	0.118
Yes	108
No	75
Tumor size (cm)	1.916 (1.121, 3.274)	0.659
< 3	121
= 3	62
Tumor number	1.317 (0.835, 2.078)	0.236
Single	147
Multiple	36
Adjacent to large vessels	0.154 (0.870, 2.418)	0.046
Yes	153
No	30
DAA therapy	0.431 (0.211, 0.791)	0.003		0.392 (0.276, 0.836)	0.023
Yes	88
No	95
a-fetoprotein level (ng/mL)	1.884 (1.271, 2.793)	0.002		1.760 (1.148, 2.698)	0.002
= 20	118
> 20	65
GGT (U/L)	1.418 (0.962, 1.712)	0.381
=50	77
>50	106
Albumin level (g/L))	0.781 (0.518, 1.177)	0.238
< 35	50
= 35	131
Total bilirubin level (µmol/L)	0.948 (0.583, 1.542)	0.829
< 20.5	150
= 20.5	33
ALT level (U/L)	0.936 (0.640, 1.368)	0.731
< 40	89
= 40	94
AST level (U/L)	0.893 (0.596, 1.336)	0.581
< 40	60
= 40	123
Platelet count (10⁹)	0.868 (0.592, 1.271)	0.466
< 100	99
= 100	84
Prothrombin time international normalized ratio	1.022 (0.682, 1.532)	0.915
< 1.1	117
= 1.1	66
Procedure session	1.877 (1.010, 3.488)	0.046
1	162
> 1	21
ChildPugh score	1.345 (0.493, 3.665)	0.563
A	175
B	8
ALBI grade	1.398 (0.950, 2.058)	0.089
1	95
2, 3	88
Data in parentheses are 95% confidence intervals. ALBI, albumin- bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase.