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Knockout of KCTD12 promotes the metastasis of melanoma cells in vivo, and the schematic illustration of the potential mechanism. (A) Body weight changes of the mice (n = 4 per group) intravenously injected with A375 and A375-KCTD12-KO cells (2 ՠ10⁶ per mouse). (B) The visceral metastasis rate of mice injected with A375 and A375-KCTD12-KO cell lines. (C) Statistical analysis of the metastatic nodes in the visceras. (D) H&E staining of the main viscera from the two groups. (E) Schematic illustration of the potential mechanism by which KCTD12 downregulation promotes melanoma metastasis.