| OC | |
SOX1
| Methylation of SOX1 was a clue to detect premalignant OC and predict recurrence as well as worse survival
| 17, 35 |
SOX2
| ① High expression level of SOX2 was exploited as a biomarker for screening OC
| 9, 16, 31, 36-39 |
| ② High expression level of SOX2 implied advanced FIGO stage together with shorter DFS
| |
| ③ SOX2 could improve cell resistance to chemo-treatment
| |
| ④ High expression of SOX2 indicated favorable DFS and OS in stage II to IV high-grade serous OC
| |
SOX7
| High expression level of SOX7 was regarded as a good prognostic marker
| 10 |
SOX11
| High expression level of SOX11 was associated with improved recurrence-free survival
| 18, 40 |
| CC | |
SOX1
| Hyper-methylation of SOX1 was an effective biomarker that can discriminate early lesions of CC from normal tissues
| 14, 41-46 |
SOX2
| ① High expression level of SOX2 was associated with higher grade along with poorer differentiation
| 7, 47-51 |
| ② Higher expression level of SOX2 indicated bigger tumor size, more metastasis and invasion as well as shorter OS and RFS
| |
| ③ High expression level of SOX2 implied radiation resistance and unfavorable prognosis
| |
| ④ High expression level of SOX2 indicated favorable DFS together with OS compared with low expression of it
| |
SOX4
| SOX4 increased cell resistance to cisplatin and contributed to progression of CC
| 52 |
SOX8 and SOX17
| Hyper-methylation of SOX8 along with SOX17 was detected more frequently in CIN3+ lesions
| 53 |
SOX9
| ① SOX9 enhanced CC cell resistance to chemo-treatment
| 54, 55 |
| ② High methylation level of SOX9 could be used as an early screening marker and indicated poor behavior of CC
| |
| EC | |
SOX1
| Analysis of high methylation index of SOX1 in patients tissues was demonstrated as a potential method for detection of EC hidden in atypical hyperplasia
| 56, 57 |
SOX2
| ① Low level of SOX2 due to hyper-methylation of CpG island upstream in promoter region indicated type II serous or clear cell adenocarcinoma and short survival
| 11, 15, 58 |
| ② High expression level of SOX2 was associated with high grade, tumor metastasis and local recurrence which implied poor outcome
| |
SOX7
| Low or absent expression level of SOX7 in tissues was associated with high grade EC
| 19 |
SOX9
| High expression level of SOX9 inhibited cell proliferative but implicated high histologic grade due to a feedback system
| 59 |
SOX17
| ① Loss of SOX17 indicated more advance stage, higher grade and shorter recurrence free-survival of patients with EC
| 21, 60, 61 |
| ② High expression level of SOX17 in tissues indicated that patients might own increased sensitivity and toxicity to cisplatin
| |