1
Effect of DM and its derivatives on heat stress-induced HSP70 expression
| |||||||
| Compound | R1 | R2 | IC50 (μM) | Compound | R1 | R2 | IC50 (μM) |
| DM |
|
| 4.60 | ||||
| 1 |
|
| 3.75 | 11 |
|
| 15.50 |
| 2 |
| 3.03 | 12 |
| 16.34 | ||
| 3 |
| 9.30 | 13 |
| 12.72 | ||
| 4 |
| 0.81 | 14 |
| 16.31 | ||
| 5 |
| 9.09 | 15 |
| 15.36 | ||
| 6 |
|
| 11.36 | 16 |
|
| 14.00 |
| 7 |
| 12.97 | 17 |
| 12.77 | ||
| 8 |
| 10.99 | 18 |
| 14.15 | ||
| 9 |
| 18.43 | 19 |
| 20.36 | ||
| 10 |
| 11.05 | 20 |
| 4.83 | ||
HeLa cells pretreated with different concentrations of DM or its derivatives were exposed to 42°C for 30 min, and HSP70 expression was examined by qRT-PCR. IC50 was calculated using the SPSS software.