S1

Clinical and pathological characteristics of the 55 patients

CharacteristicsNumber of patients (%)
Median age, years (IQR)69.1 (64.3–73.3)
Clinical NCCN risk group
 Low2 (3.6%)
 Intermediate24 (43.6%)
 High23 (41.8%
Pathologic T-category (pT)
 pT212 (21.8%)
 pT3a13 (23.6%)
 pT3b17 (30.9%)
 Tx13 (23.6%)
Pathologic N-category (pN)
 pN027 (49.1%)
 pN17 (12.7%)
 pNx21 (38.2%)
Surgical margin status
 Negative25 (45.5%)
 Positive30 (54.5%)
Pathologic Gleason score
 ≤ 64 (7.3%)
 726 (47.3%)
 ≥ 816 (29.1%)
 Unknown9 (16.3%)
ISUP grade group
 11 (1.8%)
 210 (18.2%)
 319 (34.6%)
 44 (7.3%)
 512 (21.8%)
 Unknown9 (16.3%)
Median interval between RadP
and BCR, mo (IQR)
8.05 (1.9–33.8)
Median PSA prior to 68Ga
PSMA-PET/CT, ng/ml (IQR)
2.19 (0.53–4.57)
 < 0.513
 0.5–1.08
 > 1.0–2.05
 > 2.028
 Missing1
Median PSA doubling time, mo (IQR)11.6 (6.0–21.1)
Salvage Therapy
 RT alone6 (10.9%)
 RT with HT20 (36.4%)
 HT alone13 (23.6%)
 Observation/Lost to follow up16 (29.1%)

IQR: interquartile range, PSA: prostate specific antigen, R0: negative surgical margin, R1: positive surgical margin, ISUP: International society of urological pathology grading system for prostate cancer based on Gleason score, RadP: radical prostatectomy, BCR: biochemical relapse, RT: radiotherapy, HT: hormonal therapy.